Results 171 to 180 of about 18,981 (340)

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

open access: yesVIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang   +10 more
wiley   +1 more source

In vitro digestibility of Urochloa decumbens inoculated with fungi isolated from the gastrointestinal tract of sheep

open access: yesAnnals of Applied Biology, EarlyView.
The forage digestibility decreases in the dry season. Fungus isolates from the gastrointestinal tract of healthy sheep were evaluated. Aspergillus terreus isolate was identified by analysis of rDNA and encoding β‐tubulin gene and Trichoderma longibrachiatum was identified by analysis of rDNA and elongation factor 1‐α gene. The T.
Claudio Eduardo Silva Freitas   +10 more
wiley   +1 more source

Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening

open access: yesAging Cell, EarlyView.
Larvae derived from a cross between tert deficient and haploinsufficient fish show a premature aging phenotype, characterized by telomere attrition and early death. The ST2 larval model is a valuable tool for rapid screening of antiaging molecules. Given that organogenesis occurs within the first 48 h, this model also allows for the conduction of aging
David Hernández‐Silva   +5 more
wiley   +1 more source

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound

open access: yesAging Cell, EarlyView.
Optimized low‐frequency ultrasound rejuvenates induced senescent cells and aged mice. Our results show that LFU reverses 15 aspects of senescent cells including growth and revitalizes aged mice. ABSTRACT The presence of senescent cells causes age‐related pathologies since their removal by genetic or pharmacological means, as well as possibly by ...
Sanjay K. Kureel   +8 more
wiley   +1 more source

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