Results 221 to 230 of about 9,102 (298)

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes. [PDF]

Glycobiology
Berkhout MD, Ioannou A, de Ram C, Boeren S, Plugge CM, Belzer C.   +5 more
europepmc   +1 more source

Alpha-Galactosidase ??? Genzyme General

Drugs in R & D, 2003
openaire   +2 more sources

Dietary Ergothioneine as a Novel Anti‐Aging Nutraceutical: Mechanisms, Bioavailability, and Future Perspectives

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Ergothioneine (EGT), a natural thiol derivative, has gained attention as a geroprotective nutraceutical. Preclinical research shows EGT scavenges free radicals, maintains mitochondrial integrity, slows telomere erosion, and regulates proteostasis via autophagy and senescent cell clearance.
Tian‐Tian Tian, Liang Chen, Zhen‐Zhen Dong, Chao Yang   +3 more
wiley   +1 more source

Comparative Genomic Analysis of Lactiplantibacillus plantarum: Insights into Its Genetic Diversity, Metabolic Function, and Antibiotic Resistance. [PDF]

Genes (Basel)
Li R, Bi C.
europepmc   +1 more source

Protocatechuic Acid Alleviates D‐Gal‐Induced Renal Senescence and Injury in Mice by Regulating Taurine Metabolism

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Protocatechuic acid attenuates D‐gal‐induced renal aging through regulation of CSAD‐mediated taurine metabolism, thereby alleviating oxidative stress and inflammation. ABSTRACT Protocatechuic acid (PCA), a natural phenolic compound with antioxidant and anti‐inflammatory properties, has been proposed as a potential therapeutic agent against aging ...
Songhao Tian, Tao Chen, Feng Gao, Lulu Xu, Jiarui Zhao, Yuyao Du, Zhihua Zhao   +6 more
wiley   +1 more source

Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology. [PDF]

Science
Sanguankiattichai N, Chandrasekar B, Sheng Y, Hardenbrook N, Tabak WWA, Drapal M, Kaschani F, Grünwald-Gruber C, Krahn D, Buscaill P, Yamamoto S, Kato A, Nash R, Fleet G, Strasser R, Fraser PD, Kaiser M, Zhang P, Preston GM, van der Hoorn RAL.   +19 more
europepmc   +1 more source

Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Caleb Koranteng Kwayisi‐Darkwah, Gabriel Atampugbire, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +7 more
wiley   +1 more source

Liver Gene Therapy in Fabry Disease Mice With Low Doses of rAAV2/8 Expressing a Codon‐Optimized hGLA cDNA Results in Long‐Term Disease Correction

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
AAV‐mediated gene therapy targets the liver to produce and secrete into circulation functional α‐Gal A, which is taken up by tissues to reduce glycosphingolipid accumulation and prevent disease progression in juvenile Fabry mice, even at low AAV doses. ABSTRACT Fabry disease (FD) is an X‐linked lysosomal storage disorder caused by mutations in the GLA ...
Himanshi Saxena, Rossana Domenis, Giulia Romano, Jessica Biasizzo, Martina Ferro, Dania Ferino, Antonio Vicidomini, Alessandra Iaconcig, Giulia Bortolussi, Lorena Zentilin, Andrea Dardis, Andrés F. Muro   +11 more
wiley   +1 more source

Mannans as Multifunctional Biopolymers: Structure, Properties, and Applications in Health and Industry. [PDF]

Polymers (Basel)
Karimi I, Mohammed LJ, Amshawee AM, Makki NF, Nazari K, Schiöth HB.   +5 more
europepmc   +1 more source