The molecular basis of lactase persistence: Linking genetics and epigenetics
Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen+2 more
wiley +1 more source
Metabolic insights of lactic acid bacteria in reducing off-flavors and antinutrients in plant-based fermented dairy alternatives. [PDF]
Molina GES+5 more
europepmc +1 more source
Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li+5 more
wiley +1 more source
Extremophilic Microorganisms as a Source of Emerging Enzymes for the Food Industry: A Review. [PDF]
Ashaolu TJ+4 more
europepmc +1 more source
Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. Mitochondria dysfunction occurred and tended to become round in cardiomyocytes with high m.3243A>G burden. Mitochondria‐associated ER membrane (MAM) was disrupted in cardiomyocytes with high m.3243A>G burden.
Miao Yu+10 more
wiley +1 more source
Mechanism of 2'-fucosyllactose degradation by human-associated Akkermansia. [PDF]
Padilla L+7 more
europepmc +1 more source
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika+7 more
wiley +1 more source
Research Progress on the Degradation of Human Milk Oligosaccharides (HMOs) by Bifidobacteria. [PDF]
Cai R, Zhang J, Song Y, Liu X, Xu H.
europepmc +1 more source
Cloning and characterization of a novel cold-active glycoside hydrolase family 1 enzyme with β-glucosidase, β-fucosidase and β-galactosidase activities [PDF]
core +1 more source
CHLORAMPHENICOL-PROMOTED REPRESSION OF β-GALACTOSIDASE SYNTHESIS IN ESCHERICHIA COLI
Paul S. Sypherd, Norman Strauss
openalex +1 more source