Results 131 to 140 of about 8,273 (177)

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

Carbohydrate Research, 2019
Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N ...
Cheng, Janice M.H., Chee, Stephanie H., Dolen, Y., Verdoes, M., Timmer, M., Stocker, Bridget L.   +5 more
openaire   +3 more sources

Antigenicity of Galactosylceramide

1986
Galactosylceramide (GalC) is the major glycolipid of the central nervous system (CNS) and in adult human myelin it accounts for 23% of the total lipids. The immunological properties of GalC were first detected during the search for a solution to the problem of the immunological specificity of brain lipids. Brandt et al.
B. Zalc, M. Monge, C. Lubetzki, N. A. Baumann   +3 more
openaire   +1 more source

Alpha-galactosylceramide-driven immunotherapy for allergy

Frontiers in Bioscience, 2008
We report here that the delivery of both alpha-galactosylceramide (alphaGalCer), a representative ligand for invariant natural killer T (iNKT) cells, and an antigenic polypeptide to marginal zone B cells induces the differentiation of regulatory cells in vivo, and suppresses the secondary antibody responses in mice.
Yasuyuki, Ishii, Risa, Nozawa, Yukiko, Takamoto-Matsui, Annabelle, Teng, Haruka, Katagiri-Matsumura, Hiroshi, Nishikawa, Hiroyuki, Fujita, Yuki, Tamura   +7 more
openaire   +2 more sources

Tegument galactosylceramides of the cestode Spirometra mansonoides

Molecular and Biochemical Parasitology, 1987
The brush border-like surface of the tegument of the adult and the plerocercoid larva of a pseudophyllidean cestode, Spirometra mansonoides, has been shown to contain hydroxylated galactosylceramides. D-Galactosyl-N-(2-D-hydroxyoctadecanoyl)-D-phytosphingosine, D-galactosyl-N-(2-D-hydroxyoctadecanoyl)-D-dihydrosphingosine and D-galactosyl-N ...
B N, Singh, C E, Costello, S B, Levery, R W, Walenga, D H, Beach, J F, Mueller, G G, Holz   +6 more
openaire   +2 more sources

Structural determinants of miscibility in surface films of galactosylceramide and phosphatidylcholine: effect of unsaturation in the galactosylceramide acyl chain

Biochemistry, 1991
The Langmuir film balance technique has been used to define the surface structure and determine the mixing behavior of galactosylceramide (GalCer) and phosphatidylcholines in surface phases. To determine the effect of unsaturation on surface behavior, chain-pure GalCer species containing either oleoyl (18:1 delta 9), eicosenoyl (20:1 delta 11), or ...
S, Ali, H L, Brockman, R E, Brown
openaire   +2 more sources

α-C-Galactosylceramides:  Synthesis and Immunology

Accounts of Chemical Research, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Richard W, Franck, Moriya, Tsuji
openaire   +2 more sources

Radioprotective effects of α-galactosylceramides

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract We examined the life-span-prolonging effects of five kinds of α-Galactosylceramides (α-GalCers) on mice irradiated with lethal dose (9 Gy) of X ray, and found that they show strong radioprotective activities even when they are administered to mice after the irradiation.
Kazuhiro Motoki, Eiichi Kobayashi, Masahiro Morita, Takeshi Uchida, Kohji Akimoto, Hideaki Fukushima, Yasuhiko Koezuka   +6 more
openaire   +1 more source

Exogenous Galactosylceramide as Potential Treatment for CLN3 Disease

Annals of Neurology, 2019
ObjectiveCLN3 disease is the commonest of the neuronal ceroid lipofuscinoses, a group of pediatric neurodegenerative disorders. Functions of the CLN3 protein include antiapoptotic properties and facilitating anterograde transport of galactosylceramide from Golgi to lipid rafts.
Sally El‐Sitt, Jihane Soueid, Katia Maalouf, Nadine Makhoul, Jamal Al Ali, Joelle Makoukji, Bilal Asser, Daniel Daou, Hayat Harati, Rose‐Mary Boustany   +9 more
openaire   +2 more sources

Metabolism of exogenous galactosylceramide in the twitcher mouse brain

Neurochemical Research, 1989
The in vivo metabolism of galactosylceramide (gal-cer) in normal mice and in twitcher mice, a model of human GLD, was examined following intracerebral administration of gal-cer containing [1-14C] stearic acid. In normal mice, gal-cer was hydrolyzed to ceramide within 6 hours and ceramide was hydrolyzed to sphingosine and fatty acid.
K, Mitsuo, T, Kobayashi, N, Shinnoh, I, Goto   +3 more
openaire   +2 more sources

Abnormal accumulation of galactosylceramide in the kidney of twitcher mouse

Biochemical and Biophysical Research Communications, 1983
The kidney tissue of the twitcher mice, a neurological mutant caused by a genetic deficiency of galactosylceramidase, contains enormously increased amounts, up to 50 times normal, of galactosylceramide. The finding is in sharp contrast with those in the enzymatically equivalent human disease, globoid cell leukodystrophy (Krabbe disease), in which no ...
H, Igisu, H, Takahashi, K, Suzuki, K, Suzuki   +3 more
openaire   +2 more sources