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Unique sensitivity to α-galactosylceramide of NKT cells in the uterus
Cellular Immunology, 2002It was previously reported that NKT cells, which are mainly present in the liver of mice, are also present in the uterus and that these uterine NKT cells are associated with abortion under overactivated conditions. In this study, we further examined their phenotypic and functional properties. In parallel with the progression of pregnancy, the number of
Sen, Wang +4 more
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Distribution of cholesterol and galactosylceramide in rat cerebellar white matter
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006White matter and the inner granular layer of rat cerebellum was analysed by imaging time-of-flight secondary-ion mass spectrometry (TOF-SIMS) equipped with a Bi+ ion cluster gun. Samples were prepared by high pressure freezing, freeze-fracturing and freeze drying or by plunge freezing and cryostat sectioning.
Katrin, Börner +5 more
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Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation
Bioorganic & Medicinal Chemistry Letters, 2010Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells.
Wenlan, Chen +3 more
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α-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles
Nature Reviews Immunology, 2005Autoimmune responses are normally kept in check by immune-tolerance mechanisms, which include regulatory T cells. In recent years, research has focused on the role of a subset of natural killer T (NKT) cells - invariant NKT (iNKT) cells, which are a population of glycolipid-reactive regulatory T cells - in controlling autoimmune responses. Because iNKT
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The effect of alpha-galactosylceramide upon allogenic rejection
Transplantation Proceedings, 2001K, Seino +6 more
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α-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation
American Journal of Respiratory Cell and Molecular Biology, 2005Takafumi Suda +2 more
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