Results 141 to 150 of about 8,273 (177)

Synthesis of galactosylphytosphingosine and galactosylceramides containing phytosphingosine

Chemistry and Physics of Lipids, 1974
Abstract Phytosphingosine prepared from the yeast Hansenula ciferrii was used for synthesis of galactosphingolipids. Glycosidation of N -dichloroacetyl and 3,4-di- O -benzoyl protected phytosphingosine was performed with acetobromogalactose in the presence of mercury cyanide.
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Effect of hydrogenation of glucosyl- and galactosylceramide on their enzymatic hydrolysis

Clinica Chimica Acta, 1983
Our earlier observation that N-stearoyl- and N-lignoceroyl-glucosyl-dihydro-sphingosines have much lower affinity to the hydrolytic enzyme, glucosylceramidase, than the natural mixture of glucosylceramide [11] has been further pursued with catalytically hydrogenated natural substrate.
A M, Vaccaro, M, Muscillo, K, Suzuki
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Immunostimulatory activities of mono- or diglycosylated α-galactosylceramides

Bioorganic & Medicinal Chemistry, 1997
We examined the effects of 2"- or 3"-monoglycosylated alpha-galactosylceramides (alpha-GalCers) and 2",3"-diglycosylated alpha-GalCers on allogeneic MLR and the proliferation of murine spleen cells. It was found that their ceramide portions greatly affect their immunostimulatory activities, and that the 3"-hydroxyl group plays a more important role in ...
A, Uchimura, T, Shimizu, M, Nakajima, H, Ueno, K, Motoki, H, Fukushima, T, Natori, Y, Koezuka   +7 more
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Drastically Abnormal Gluco- and Galactosylceramide Composition Does Not Affect Ganglioside Metabolism in the Brain of Mice Deficient in Galactosylceramide Synthase

Neurochemical Research, 1999
Mice that are genetically deficient in UDP-galactose: ceramide galactosyltransferase are unable to synthesize galactosylceramide. Consequently, sulfatide, which can be synthesized only by sulfation of galactosylceramide, is also totally absent in affected mouse brain.
K, Suzuki, M T, Vanier, T, Coetzee, B, Popko   +3 more
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Acyl structure regulates galactosylceramide's interfacial interactions

Biochemistry, 1993
Galactosylceramides (GalCer) with homogeneous acyl chains containing zero, one, or two cis double bonds have been synthesized and characterized at an argon-aqueous buffer interface using a Langmuir film balance. Both surface pressure and surface potential were measured as a function of molecular area at 24 degrees C. N-Lignoceroylgalactosylsphingosine (
S, Ali, J M, Smaby, R E, Brown
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Use of Mixed Dispersion of Fluorescent Galactosylceramide and Sodium Dodecylsulfate for Assaying Galactosylceramide-β-Galactosidase and Diagnosing Krabbe Disease

Enzyme, 2017
A fluorescent derivative of galactosylceramide [NBD-GalCer: 12-N-methyl-N- (7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminodecanoyl galactosylceramide] was dispersed in sodium dodecylsulfate and used to determine the activity of galactosylceramide-β-galactosidase.
R, Salvayre, S, Gatt
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Optical Control of Cytokine Production Using Photoswitchable Galactosylceramides

Chemistry – A European Journal, 2020
Abstractα‐Galactosylceramides are glycosphingolipids that show promise in cancer immunotherapy. After presentation by CD1d, they activate natural killer T cells (NKT), which results in the production of a variety of pro‐inflammatory and immunomodulatory cytokines.
Hartrampf, Nina, Seki, Toshiyuki, Baumann, Andreas, Watson, Philip, Vepřek, Nynke A, Hetzler, Belinda E, Hoffmann‐Röder, Anja, Tsuji, Moriya, Trauner, Dirk   +8 more
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Effect of Galactosylceramide on the Dynamics of Cholesterol-Rich Lipid Membranes

The Journal of Physical Chemistry B, 2011
We use atom-scale molecular dynamics simulations to clarify the role of glycosphingolipids in the dynamics of cholesterol-rich lipid rafts. To this end, we consider lipid membranes that contain varying amounts of galactosylceramide (GalCer), sphingomyelin, cholesterol, and phosphatidylcholine.
Hall Anette, Vattulainen Ilpo, Rog Tomasz, Vattulainen Ilpo   +3 more
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Glucosylceramide and Galactosylceramide Synthase

2006
Most mammalian glycosphingolipid formation begins with the synthesis of cerebrosides, glucosylceramide and galactosylceramide. The synthases catalyzing the formations of glucosylceramide (GlcCer) and galactosylceramide (GalCer) have been characterized at the gene and protein levels.
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Clinical Trials with α-Galactosylceramide (KRN7000) in Advanced Cancer

2011
For over a century, research has sought ways to boost the immune system of cancer patients in order to eradicate tumors that arose after escaping presumptive immunosurveillance. With increasing knowledge of the immune system, immunotherapeutic strategies to break tolerance to the tumor evolved from largely nonspecific to more specific and increasingly ...
Schneiders, Famke L., Scheper, Rik J., Bontkes, Hetty J., von Blomberg, B. Mary E., Eertwegh, Alfons J.M., de Gruijl, Tanja D., Van Der Vliet, Hans J.   +6 more
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