Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury
Molecular Medicine, 2015 Natural killer T (NKT) cells are a subset of lymphocytes that reacts to glycolipids presented by CD1d. Invariant NKT cells (iNKT) correspond to >90% of the total population of NKTs and reacts to α-galactosylceramide (αGalCer). αGalCer promotes a complex mixture of Th1 and Th2 cytokines, as interferon (IFN)-γ and interleukin (IL)-4.
Cristhiane Favero, Aguiar +11 more
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NKT cells in the antitumor response: the β version? [PDF]
NKT cells recognize glycolipids presented by CD1d-expressing antigen-presenting cells (APCs) and include type I NKT cells with antitumor function and type II NKT cells, which have been reported to suppress the antitumor response.
Engel, Isaac, Kronenberg, Mitchell
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Gas Phase Infrared Spectroscopy of Glycolipids
, 2019 Carbohydrates and lipids are not only energy sources and structural components of cells but fulfill very diverse and important roles in a multitude of cellular processes. The combination of a carbohydrate and a lipid linked via a glycosidic bond yields a
Kirschbaum, C.
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FA2H Dependent Fatty Acid 2-Hydroxylation in the Mammalian Nervous System [PDF]
, 2007 Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. This unique membrane is comprised of approximately 70% lipid and 30% protein.
Alderson, Nathan Lance
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Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload [PDF]
, 2020 Heterozygous mutations of the lysosomal enzyme glucocerebrosidase (GBA1) represent the major genetic risk for Parkinson’s disease (PD), while homozygous GBA1 mutations cause Gaucher disease, a lysosomal storage disorder, which may involve severe ...
Bhosale, G +10 more
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Controlled cholesterol efflux from the aortic smooth muscle cells triggers microheterogeneity of plasma membrane lipids and induces modification of the mitochondrial topology [PDF]
, 2009 It is generally accepted that phospholipids of plasma membrane display lateral segregation into small microdomains commonly known as lipid rafts. Such lateral lipid organization is under the control of cholesterol. Cholesterol depletion evolved by methyl-
Drózd, K. +6 more
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A new glucocerebrosidase chaperone reduces α-synuclein and glycolipid levels in iPSC-derived dopaminergic neurons from patients with gaucher disease and parkinsonism [PDF]
, 2016 et al, +3 more
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AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease) [PDF]
, 2018 et al,, Jiang, Xuntain, Ory, Daniel S
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