Results 41 to 50 of about 4,713 (170)
Mixed Signals: T Cells as Architects of IgE Immunity
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney +3 more
wiley +1 more source
Suppression of eosinophilic airway inflammation by treatment with α‐galactosylceramide [PDF]
European Journal of Immunology, 2005 AbstractTo clarify the essential role of NKT cells in allergy, we investigated the contribution of NKT cells to the pathogenesis of eosinophilic airway inflammation using α‐galactosylceramide (α‐GalCer), a selective ligand for NKT cells. Although continuous administration of α‐GalCer during ovalbumin (OVA) sensitization increased OVA‐specific IgE ...
Yuko, Morishima +12 more
openaire +2 more sources
Food Science &Nutrition, Volume 14, Issue 4, April 2026.This graphical abstract illustrates the gut microenvironment disparities between breastfed and formula‐fed infants at 6 months of age. Through multi‐omics analysis, breastfeeding was shown to establish a distinct ecological imprinting characterized by favorable microbial shifts and down‐regulated pro‐inflammatory arachidonic acid metabolism, thereby ...
Simin Zhu +4 more
wiley +1 more source
Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz +24 more
wiley +1 more source
Heparan Sulfate Proteoglycans in Immunity
Proteoglycan Research, Volume 4, Issue 2, April 2026.ABSTRACT In immune cells, heparin was first identified in mast cells in the 1940s, followed by the discovery of heparan sulfate in lymphocytes and granulocytes during the 1970s and 1980s. Subsequent decades of research have revealed how heparan sulfate and heparin, conjugated to core proteins as heparan sulfate proteoglycans (HSPGs), act as versatile ...
Moe Iwai, Pyong Woo Park
wiley +1 more source
Brain‐X, Volume 4, Issue 1, March 2026.Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang +17 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 3, March 2026.We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé +6 more
wiley +1 more source