Results 31 to 40 of about 4,713 (170)
Small, EarlyView.Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito +9 more
wiley +2 more sources
Host immunomodulatory lipids created by symbionts from dietary amino acids
Nature, 2021 Small molecules derived from symbiotic microbiota critically contribute to intestinal immune maturation and regulation1. However, little is known about the molecular mechanisms that control immune development in the host–microbiota environment.
Sungwhan F. Oh +14 more
semanticscholar +1 more source
Activation or anergy: NKT cells are stunned by -galactosylceramide [PDF]
Journal of Clinical Investigation, 2005 Invariant natural killer T (iNKT) cells are T lymphocytes that behave similarly to cells of the innate immune system. The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent and specific activator of mouse and human iNKT cells and has been used in cancer clinical trials to drive NKT cell-mediated immune responses.
Barbara A, Sullivan +1 more
openaire +2 more sources
The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development
European Journal of Immunology, Volume 56, Issue 5, May 2026.YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze +7 more
wiley +1 more source
Thermotropic behavior of galactosylceramides with cis-monoenoic fatty acyl chains.
Biochimica et Biophysica Acta, 1998 To define the thermotropic behavior of galactosylceramides (GalCer) containing cis monounsaturated acyl chains, N-X:1Delta(X-9) cis galactosylsphingosines (GalSph) were synthesized (where X=24, 22, 20, or 18) and investigated by differential scanning ...
V. Kulkarni, Rhoderick E. Brown
semanticscholar +1 more source
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Synthesis of Galactosylceramide and Glucosylceramide by Mouse Kidney Preparations
Journal of Biological Chemistry, 1973 A particulate fraction was prepared from kidneys, lyophilized, and coated with ceramide. After incubation with UDP-[14C]Gal and appropriate cofactors, the major radioactive component in the lipid fraction was galactosylceramide (Gal-Cer). If UDP-Glc was substituted for UDP-Gal, the product was glucosylceramide (Glc-Cer).
E, Costantino-Ceccarini, P, Morell
openaire +2 more sources
Sphingomyelin Modulates the Transbilayer Distribution of Galactosylceramide in Phospholipid Membranes [PDF]
Journal of Biological Chemistry, 2002 The interrelationships among sphingolipid structure, membrane curvature, and glycosphingolipid transmembrane distribution remain poorly defined despite the emerging importance of sphingolipids in curved regions and vesicle buds of biomembranes. Here, we describe a novel approach to investigate the transmembrane distribution of galactosylceramide in ...
Peter, Mattjus +5 more
openaire +2 more sources
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source