Results 21 to 30 of about 4,713 (170)

C-galactosylceramide: Synthesis and immunology [PDF]

Comptes Rendus. Chimie, 2011
A synthetic C-glycoside, α-C-galactosylceramide, is an active immunostimulant in mice. It displays better activity than α-O-galactosylceramide in several disease models. Syntheses of several α-C-galactosylceramides are described. Experiments that probe its immunostimulant activity are outlined.
openaire   +2 more sources

Prophylaxis of lipopolysaccharide-induced shock by α-galactosylceramide [PDF]

Journal of Leukocyte Biology, 2008
AbstractThe NKT cell ligand α-galactosylceramide and its synthetic homologue KRN7000 stimulate rapid and copious secretion of IFN-γ and TNF-α release, both of which are key mediators of LPS-induced shock. We showed that KRN7000, injected before or within 2 h after LPS challenge, was able to prevent endotoxic shock.
Guido, Sireci, Marco Pio, La Manna, Diana, Di Liberto, Marco, Lo Dico, Masaru, Taniguchi, Francesco, Dieli, Alfredo, Salerno   +6 more
openaire   +2 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Structural Analysis of Fungal Cerebrosides

Frontiers in Microbiology, 2011
Of the ceramide monohexosides (CMHs), gluco- and galactosylceramides are the main neutral glycosphingolipids expressed in fungal cells. Their structural determination is greatly dependent on the use of mass spectrometric techniques, including fast atom ...
Eliana eBarreto-Bergter, Guilherme Lanzi Sassaki, Lauro eSouza   +2 more
doaj   +1 more source

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid[S]

Journal of Lipid Research, 2019
Cerebrosides, including glucosylceramides (GlcCers) and galactosylceramides (GalCers), are important membrane components of animal cells with deficiencies resulting in devastating lysosomal storage disorders. Their quantification is essential for disease
Hongbin Xu, Frederic R. Boucher, Thao T. Nguyen, Graeme P. Taylor, Julianna J. Tomlinson, Roberto A. Ortega, Brigitte Simons, Michael G. Schlossmacher, Rachel Saunders-Pullman, Walt Shaw, Steffany A.L. Bennett   +10 more
doaj   +1 more source

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

Molecular Cancer, 2010
Background Sulfatides (ST) are a category of sulfated galactosylceramides (GalCer) that are elevated in many types of cancer including, possibly, ovarian cancer.
McDonald John F, Walker L, Matyunina Lilya V, Bowen Nathan J, Wang Elaine, Shaner Rebecca, Momin Amin, Chen Yanfeng, Liu Ying, Sullards M, Merrill Alfred H   +10 more
doaj   +1 more source

The First Total Synthesis of Immunostimulant α-Galactosylceramides from Naturally Configured α-Galactoside Raffinose

Organic Letters, 2011
The total synthesis of absolute anomeric confirmation α-galactosylceramide analogues from raffinose is described. Using the naturally occurring α-galactoside raffinose as the starting material, the easily maneuverable protocol without glycosylation ...
Zhenxing Zhang, Wei Zhao, Bin Wang, C. Xia, Wenpeng Zhang, P. Wang   +5 more
semanticscholar   +1 more source

Sulfatide inhibits  -galactosylceramide presentation by dendritic cells [PDF]

International Immunology, 2012
Sulfatide-reactive type II NKT cells, the so-called non-invariant NKT (non-iNKT) cells, have been shown to counteract invariant NKT (iNKT) cell activity. However, the effects of sulfatide on activation of iNKT cells by α-galactocylceramide (αGC) in the context of CD1d have not been studied in detail.
Mitsuhiro, Kanamori, Yusuke, Tasumi, Tomonori, Iyoda, Maki, Ushida, Kayo, Inaba   +4 more
openaire   +2 more sources

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source