Results 11 to 20 of about 4,713 (170)

Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods

Frontiers in Microbiology, 2021
Filamentous fungi are a group of economically important fungi used in the production of fermented foods, industrial enzymes, and secondary metabolites. Glycosphingolipids (GSLs) as constituents of lipid rafts are involved in growth, differentiation, and ...
Chunmiao Jiang, Jinxin Ge, Bin He, Bin Zeng, Bin Zeng   +4 more
doaj   +1 more source

CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism

Journal of Lipid Research, 2021
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT.
Christopher D. Green, Cynthia Weigel, Clement Oyeniran, Briana N. James, Deanna Davis, Usha Mahawar, Jason Newton, Binks W. Wattenberg, Michael Maceyka, Sarah Spiegel   +9 more
doaj   +1 more source

High-Density Lipoprotein Lipidomics and Mortality in CKD

Kidney Medicine, 2023
Rationale & Objective: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes.
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal   +8 more
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Vitamin K enhances the production of brain sulfatides during remyelination. [PDF]

PLoS ONE, 2018
Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system.
Daniela C Popescu, He Huang, Naveen K Singhal, Leah Shriver, Jennifer McDonough, Robert J Clements, Ernest J Freeman   +6 more
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Quantitative analysis of brain galactosylceramides by high performance liquid chromatography of their perbenzoyl derivatives

Journal of Lipid Research, 1976
A high performance liquid chromatographic (HPLC) method for analysis of galactosylceramides as their benzoyl derivatives has been devised. Samples containing 10-150 nmoles of monohexosylceramides are benzoylated by heating for 60 min at 60 ° C in 0.5 ml ...
E H McCluer, J E Evans
doaj   +1 more source

Identification of a xylose-containing cerebroside in the salt gland of the herring gull

Journal of Lipid Research, 1972
A pentose-containing cerebroside has been identified in the salt gland of the herring gull, using mass spectrometry of acetyl and trimethylsilyl derivatives.
Karl-Anders Karlsson, Bo E. Samuelsson, Göran O. Steen   +2 more
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Impact of galactosylceramides on the nanomechanical properties of lipid bilayer models: an AFM-force spectroscopy study.

Soft Matter, 2015
Galactosylceramides (GalCer) are glycosphingolipids bound to a monosaccharide group, responsible for inducing extensive hydrogen bonds that yield their alignment and accumulation in the outer leaflet of the biological membrane together with cholesterol ...
Berta Gumí‐Audenis, F. Sanz, M. Giannotti   +2 more
semanticscholar   +1 more source

Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside[S]

Journal of Lipid Research, 2016
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the presence ...
Hisako Akiyama, Kazuki Nakajima, Yoshiyuki Itoh, Tomoko Sayano, Yoko Ohashi, Yoshiki Yamaguchi, Peter Greimel, Yoshio Hirabayashi   +7 more
doaj   +1 more source

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

FASEB BioAdvances, 2019
Very‐long‐chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders involving skin ...
Masashi Isokawa, Takayuki Sassa, Satoko Hattori, Tsuyoshi Miyakawa, Akio Kihara   +4 more
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Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers[S]

Journal of Lipid Research, 2009
Sphingolipids are a highly diverse category of bioactive compounds. This article describes methods that have been validated for the extraction, liquid chromatographic (LC) separation, identification and quantitation of sphingolipids by electrospray ...
Rebecca L. Shaner, Jeremy C. Allegood, Hyejung Park, Elaine Wang, Samuel Kelly, Christopher A. Haynes, M. Cameron Sullards, Alfred H. Merrill, Jr.   +7 more
doaj   +1 more source