Results 81 to 90 of about 633 (112)

Optical Control of Cytokine Production Using Photoswitchable Galactosylceramides

Chemistry – A European Journal, 2020
Abstractα‐Galactosylceramides are glycosphingolipids that show promise in cancer immunotherapy. After presentation by CD1d, they activate natural killer T cells (NKT), which results in the production of a variety of pro‐inflammatory and immunomodulatory cytokines.
Hartrampf, Nina, Seki, Toshiyuki, Baumann, Andreas, Watson, Philip, Vepřek, Nynke A, Hetzler, Belinda E, Hoffmann‐Röder, Anja, Tsuji, Moriya, Trauner, Dirk   +8 more
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α-C-Galactosylceramides:  Synthesis and Immunology

Accounts of Chemical Research, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Richard W, Franck, Moriya, Tsuji
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Radioprotective effects of α-galactosylceramides

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract We examined the life-span-prolonging effects of five kinds of α-Galactosylceramides (α-GalCers) on mice irradiated with lethal dose (9 Gy) of X ray, and found that they show strong radioprotective activities even when they are administered to mice after the irradiation.
Kazuhiro Motoki, Eiichi Kobayashi, Masahiro Morita, Takeshi Uchida, Kohji Akimoto, Hideaki Fukushima, Yasuhiko Koezuka   +6 more
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Tegument galactosylceramides of the cestode Spirometra mansonoides

Molecular and Biochemical Parasitology, 1987
The brush border-like surface of the tegument of the adult and the plerocercoid larva of a pseudophyllidean cestode, Spirometra mansonoides, has been shown to contain hydroxylated galactosylceramides. D-Galactosyl-N-(2-D-hydroxyoctadecanoyl)-D-phytosphingosine, D-galactosyl-N-(2-D-hydroxyoctadecanoyl)-D-dihydrosphingosine and D-galactosyl-N ...
B N, Singh, C E, Costello, S B, Levery, R W, Walenga, D H, Beach, J F, Mueller, G G, Holz   +6 more
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A protein activator of galactosylceramide β-galactosidase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
A heat-stable protein was isolated from the spleen of a patient with Gaucher's disease. This protein will activate glucosylceramide beta-glucosidase activity (Ho, M.W. and O'Brien, J.S. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 2810-2813). When the specificity of this activator was tested using other enzymes and substrates, it was found to activate ...
D A, Wenger, M, Sattler, S, Roth
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An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

Carbohydrate Research, 2019
Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N ...
Cheng, Janice M.H., Chee, Stephanie H., Dolen, Y., Verdoes, M., Timmer, M., Stocker, Bridget L.   +5 more
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An Efficient and Concise Synthesis of α-Galactosylceramide

Synlett, 2020
AbstractA concise and stereoselective synthesis of α-galactosylceramide (α-GalCer) is described. The key features of the synthetic strategy are the use of a phytosphingosine in which the amine is masked as a tetrachlorophthalimide and the diol as an isopropylidene acetal, and the galactosyl donor is protected as a 4,6-benzylidene to improve the α ...
Daniela Imperio, Laura Morelli, Federica Compostella, Luigi Panza   +3 more
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Occurrence of galactosylceramide in pig epidermal cells

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
Monoglycosylceramides were isolated from pig epidermal cells which had been prepared free from dermal elements. The most polar glycolipid among the five isolated monoglycosylceramides was galactosylceramide. The galactosylceramide was composed of alpha-hydroxypalmitic acid and 16- and 18-carbon chain sphingenine, being quite different from epidermal ...
S, Hamanaka, Y, Yamaguchi, T, Yamamoto, C, Asagami   +3 more
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Antigenicity of Galactosylceramide

1986
Galactosylceramide (GalC) is the major glycolipid of the central nervous system (CNS) and in adult human myelin it accounts for 23% of the total lipids. The immunological properties of GalC were first detected during the search for a solution to the problem of the immunological specificity of brain lipids. Brandt et al.
B. Zalc, M. Monge, C. Lubetzki, N. A. Baumann   +3 more
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Two novel galactosylceramides from Marphysa sanguinea

Tetrahedron Letters, 1992
Abstract Two galactosylceramides carrying the phosphocholine group were isolated in the pure state from a marine annelid, Marphysa sanguinea, and their structures were determined. Two galactosylceramides carrying the phosphocholine group were isolated from Marphysa sanguinea, and their structures were determined.
Naoki Noda, Ryuichuo Tanaka, Kazumoto Miyahara, Toshio Kawasaki   +3 more
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