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Total Synthesis of (±)-Galanthamine
Organic Letters, 2006 [reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation ...
Xiang-Dong, Hu +7 more
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Review of the acetylcholinesterase inhibitor galanthamine
Expert Opinion on Investigational Drugs, 2000Galanthamine (or galantamine, Reminyl) is a tertiary alkaloid acetylcholinesterase inhibitor (AChEI) which has been approved in several countries for the symptomatic treatment of senile dementia of the Alzheimer's type. Derived from bulbs of the common snowdrop and several Amaryllidaceae plants, (-)-galanthamine (GAL) has long been used in anaesthetics
J J, Sramek +2 more
exaly +3 more sources
Drugs & Aging, 1996
Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue.
B, Fulton, P, Benfield
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Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue.
B, Fulton, P, Benfield
+5 more sources
Galanthamine hydrobromide in mania
Lancet, The, 1991Ernir Snorrason, JónG. Stefánsson
exaly +2 more sources
The Optical Resolution of (±)-Galanthamine
HETEROCYCLES, 1976 Tetsuji Kametani +2 more
openaire +2 more sources