Galantamine-loaded PLGA nanoparticles reduce oxidative stress and inflammation in a rat model of spinal cord injury [PDF]
Scientific ReportsSpinal cord injury (SCI) represents a debilitating condition with no effective treatments currently available. Previous research demonstrated that galantamine improves functional outcomes in SCI models. However, systemic administration results in limited
Fernanda Stapenhorst Franca +7 more
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Galantamine plasma concentration and cognitive response in Alzheimer’s disease [PDF]
PeerJ, 2019 Background Galantamine has been approved for the treatment of Alzheimer’s disease (AD). However, there are few studies which have reported the association between cognitive responses and galantamine plasma concentration.
Yi-Ting Lin +3 more
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Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever
Molecular Medicine, 2022 Background Autoinflammatory diseases, a diverse group of inherited conditions characterized by excessive innate immune activation, have limited therapeutic options.
Ibrahim T. Mughrabi +10 more
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Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice
Scientific Reports, 2023 Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome.
Qinghe Meng +5 more
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Pharmaceuticals, 2021 Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–
Jan Bures +8 more
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The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats [PDF]
Disease and Diagnosis, 2019 Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and
Majid Askaripour +2 more
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Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice.
Saeed Sadigh-Eteghad +3 more
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Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice
Frontiers in Neuroscience, 2023 Introduction:Prolonged oxygen therapy in preterm infants often leads to cognitive impairment. Hyperoxia leads to excess free radical production with subsequent neuroinflammation, astrogliosis, microgliosis and apoptosis. We hypothesized that Galantamine,
Nahla Zaghloul +5 more
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Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma
Neurobiology of Disease, 2020 Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer's ...
Sarah Naguib +4 more
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Metabolites, 2021 Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich +4 more
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