Galantamine ameliorates experimental pancreatitis
Molecular Medicine, 2023 Background Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response activated by vagus nerve-dependent
Dane A. Thompson +9 more
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Reactions Weekly, 2017 In 1906, Alois Alzheimer, a psychiatrist from Munich, Germany, described a new mental illness, which is a progressively damaging brain disorder, leading to neurodegeneration, erosion of basic intellectual functions along with histological changes, and ultimately the patient’s death.
John C. Courtney +1 more
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Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system. [PDF]
Alzheimers DementAbstract INTRODUCTION Alzheimer's Disease (AD) is a central nervous system (CNS) neurodegenerative disease leading to dementia, but can also show symptoms of motor deficits. It is not clear whether the peripheral motor deficits in AD are derived from upstream centers or intrinsic to the neuromuscular circuit.
Kargazhanov A +11 more
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Comparative study of the vibrational optical activity techniques in structure elucidation : the case of galantamine [PDF]
, 2019 The absolute configuration of the alkaloid galantamine was studied using a range of solution-state techniques; nuclear magnetic resonance (NMR), vibrational circular dichroism (VCD), and Raman optical activity (ROA). While the combined use of NMR and VCD
Bultinck, Patrick +4 more
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Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]
, 2009 Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz +21 more
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REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder [PDF]
, 2020 Increasing evidence supports a close link between REM sleep and the consolidation of emotionally toned memories such as traumatic experiences. In order to investigate the role of sleep for the development of symptoms related to traumatic experiences ...
Bublitz, Jan Christoph +6 more
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Journal of Neuroinflammation, 2021 Background Binge ethanol exposure during adolescence reduces hippocampal neurogenesis, a reduction which persists throughout adulthood despite abstinence.
Victoria Macht +3 more
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The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]
, 2017 Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela +3 more
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Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]
, 2016 Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
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Can we predict the response to Galantamine in Alzheimer`s disease patients? [PDF]
Romanian Journal of Neurology, 2015 Although considerate progress was obtained by adding imagistic and laboratory test, clinical examination remains the core of the diagnosis for Alzheimer`s disease. After 20 years of experience with anticholinergic drugs we know that only one third of the
Carmen Gavan +2 more
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