Results 11 to 20 of about 11,885 (204)
Galantamine-loaded PLGA nanoparticles reduce oxidative stress and inflammation in a rat model of spinal cord injury [PDF]
Scientific ReportsSpinal cord injury (SCI) represents a debilitating condition with no effective treatments currently available. Previous research demonstrated that galantamine improves functional outcomes in SCI models. However, systemic administration results in limited
Fernanda Stapenhorst Franca +7 more
doaj +2 more sources
Clinical Interventions in Aging, 2008 Richard A Hansen1, Gerald Gartlehner2, Aaron P Webb1, Laura C Morgan3, Charity G Moore4, Daniel E Jonas31School of Pharmacy, 3Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC, USA; 2Department for Evidence ...
Richard A Hansen +5 more
doaj +1 more source
Neuropsychiatric Disease and Treatment, 2017 Ryoko Nakagawa,1 Takashi Ohnishi,1 Hisanori Kobayashi,1 Toshio Yamaoka,2 Tsutomu Yajima,3 Ai Tanimura,4 Toshiya Kato,4 Kazutake Yoshizawa1 1Evidence Generation Department, Medical Affairs Division, 2Clinical Data Management Department, R&D Division,
Nakagawa R +7 more
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Restoring Septohippocampal Cholinergic Signaling Rescues Surgery-Induced Neurogenesis and Memory Deficits in Aged Mice. [PDF]
Aging CellSurgery‐induced MS/vDB → DG cholinergic decline impairs hippocampal neurogenesis and memory in aged mice; galantamine‐mediated cholinergic potentiation or sustained chemogenetic activation rescues these deficits, highlighting therapeutic potential for POCD.
Lei L +8 more
europepmc +2 more sources
ChemTexts, 2017 In 1906, Alois Alzheimer, a psychiatrist from Munich, Germany, described a new mental illness, which is a progressively damaging brain disorder, leading to neurodegeneration, erosion of basic intellectual functions along with histological changes, and ultimately the patient’s death.
Bernd Janssen, Bernd Schäfer
+4 more sources
Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice
Scientific Reports, 2023 Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome.
Qinghe Meng +5 more
doaj +1 more source
Pharmaceuticals, 2021 Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoea (5–
Jan Bures +8 more
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Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice.
Saeed Sadigh-Eteghad +3 more
doaj +1 more source
The Effect of Galantamine on Liver Function in Hepatic Ischemia/Reperfusion Injury in Rats [PDF]
Disease and Diagnosis, 2019 Background: Hepatic ischemia-reperfusion (IR) injury may affect different biological and functional roles of the liver. The present study aims to evaluate the effects of galantamine as a cholinergic agent on the acute and late phases of IR. Materials and
Majid Askaripour +2 more
doaj +1 more source
Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma
Neurobiology of Disease, 2020 Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer's ...
Sarah Naguib +4 more
doaj +1 more source