Results 11 to 20 of about 9,994 (168)

Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma

Neurobiology of Disease, 2020
Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer's ...
Sarah Naguib, Alexandra Bernardo-Colón, Caroline Cencer, Neha Gandra, Tonia S. Rex   +4 more
doaj   +1 more source

Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel

Metabolites, 2021
Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen, Soliman Khatib   +4 more
doaj   +1 more source

Can we predict the response to Galantamine in Alzheimer`s disease patients? [PDF]

Romanian Journal of Neurology, 2015
Although considerate progress was obtained by adding imagistic and laboratory test, clinical examination remains the core of the diagnosis for Alzheimer`s disease. After 20 years of experience with anticholinergic drugs we know that only one third of the
Carmen Gavan, Cristina Tiu, Ovidiu Alexandru Bajenaru   +2 more
doaj   +1 more source

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial

Frontiers in Immunology, 2021
Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation and altered neural autonomic regulation, are important components and drivers of ...
Carine Teles Sangaleti, Carine Teles Sangaleti, Keyla Yukari Katayama, Kátia De Angelis, Kátia De Angelis, Tércio Lemos de Moraes, Amanda Aparecida Araújo, Heno F. Lopes, Heno F. Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Cláudia Irigoyen, Peder S. Olofsson, Peder S. Olofsson, Douglas P. Barnaby, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim Colombo, Fernanda Marciano Consolim Colombo   +19 more
doaj   +1 more source

Galantamine prevents and reverses neuroimmune induction and loss of adult hippocampal neurogenesis following adolescent alcohol exposure

Journal of Neuroinflammation, 2021
Background Binge ethanol exposure during adolescence reduces hippocampal neurogenesis, a reduction which persists throughout adulthood despite abstinence.
Victoria Macht, Ryan Vetreno, Natalie Elchert, Fulton Crews   +3 more
doaj   +1 more source

Galantamine Effects on Memory, Spatial Cue Utilization, and Neurotrophic Factors in Aged Female Rats

Cell Transplantation, 2007
Galantamine is an acetylcholine esterase inhibitor that has been approved for use in Alzheimer's disease. However, even though clinical studies indicate efficacy in attenuating some of the symptoms associated with the disease, there are a paucity of ...
K. L. French, H. A. Bimonte-Nelson, A.-Ch. Granholm   +2 more
doaj   +1 more source

Effects of Galantamine and Donepezil on Active and Passive Avoidance Tests in Rats With Induced Hypoxia

Journal of Pharmacological Sciences, 2006
.: The cholinergic system undergoes changes with aging and in Alzheimer’s disease. The effects of the anticholinesterase drugs galantamine and donepezil were studied in a model with sodium nitrite-induced hypoxia in rats.
Dimitrova Darinka Slavcheva, Getova-Spassova Damianka Peteva   +1 more
doaj   +1 more source

Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy

Pharmaceutics, 2020
In the present study, poly(l-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLGA) hybrid nanoparticles were developed for intranasal delivery of galantamine, a drug used in severe to moderate cases of Alzheimer’s disease. Galantamine (GAL) was
Stavroula G. Nanaki, Konstantinos Spyrou, Chryssa Bekiari, Pelagia Veneti, Turki N. Baroud, Niki Karouta, Ioannis Grivas, Georgios C. Papadopoulos, Dimitrios Gournis, Dimitrios N. Bikiaris   +9 more
doaj   +1 more source

Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug.

PLoS ONE, 2015
The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate its ...
Mennatallah A Ali, Hanan S El-Abhar, Maher A Kamel, Ahmed S Attia   +3 more
doaj   +1 more source

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive efficacy compared to oral ...
Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld   +7 more
doaj   +1 more source