Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS [PDF]
, 2018 Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents.
Brunetti, Luigi +12 more
core +6 more sources
The influence of in vitro gastrointestinal digestion on the chemical composition and antioxidant and enzyme inhibitory capacities of carob liqueurs obtained with different elaboration techniques [PDF]
, 2019 Carob liqueur is a traditional Mediterranean alcoholic beverage obtained via a wide range of production techniques contributing to the different organoleptic attributes of the final product.
Coelho, Natacha +5 more
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ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders).
Patrick Müller +6 more
doaj +1 more source
Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease
Brain Sciences, 2021 Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool +3 more
doaj +1 more source
New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation [PDF]
, 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE).
Chiarotto, Isabella +9 more
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Ibrain, EarlyView.Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen +9 more
wiley +1 more source
NICE 2011 recommendations on the management of Alzheimer’s disease by acetylcholinesterase inhibitors and memantine [PDF]
, 2011 The National Institute of Clinical Excellence (NICE) has lately overturned its decision to restrict the use of acetycholinesterase inhibitors and memantine in patients diagnosed with Alzheimer’s disease (AD).
Scerri, Charles
core
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]
, 2008 We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel +81 more
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Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca +3 more
wiley +1 more source