Results 41 to 50 of about 9,994 (168)

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6606-6616, 30 August 2026.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib, Luis Felipe Hernández‐Ayala, Silvana Silva‐Aguirre, Annia Galano   +3 more
wiley   +1 more source

Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking

Archives of Insect Biochemistry and Physiology, Volume 122, Issue 4, August 2026.
Optimized extracts from Ficus carica pruning waste exhibit strong biological activity against major stink bug pests. Complementary in silico analyses suggest this efficacy relies on pest‐specific acetylcholinesterase inhibition, predicting a promising, pollinator‐safe alternative for sustainable agriculture.
Thais A. Almeida, Arley R. Páez, Lara T. M. Costa, Guy Smagghe, Yara M. Cardoso, Letícia M. Faria, Eugênio E. Oliveira, João Paulo V. Leite   +7 more
wiley   +1 more source

Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer’s dementia: A systematic review

Brain Circulation
BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) are widely used in Alzheimer’s disease (AD). This study aims to systematically review the literature about movement disorders (MDs) associated with AChEIs for AD, which include donepezil, galantamine ...
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara   +1 more
doaj   +1 more source

Alzheimer's disease - a review of medicinal substances and their derivatives [PDF]

Farmacja Polska
Alzheimer’s disease (AD) is a neurodegenerative disorder. Although the first case of Alzheimer’s disease was recorded over a century ago, the etiology of the disease remains unknown. There are several hypotheses regarding the process of neurodegeneration,
Marika Więcek, Dorota G. Piotrowska, Michał Kołodziejczyk, Iwona E. Głowacka   +3 more
doaj   +1 more source

Phytochemical Profiling and Biological Evaluation of Anthyllis henoniana Organs: Integrated In Vitro and Molecular Docking Insights Into Antioxidant, Anti‐Inflammatory, and Cytotoxic Potential

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Anthyllis henoniana aerial parts were subjected to fractionated extraction. Methanolic fractions yielded high total phenolic and flavonoid contents with strong antiradical (anti‐DPPH) and neuroprotective (anti‐AChE) activities, whereas dichloromethane and cyclohexane fractions demonstrated potent cytotoxicity (anti‐MCF‐7, anti‐HCT‐116) and anti ...
Sabrine Jaber, Rami Rahmani, Jalloul Bouajila, Mohamed Debouba   +3 more
wiley   +1 more source

Galantamine-Memantine Combination in the Treatment of Parkinson’s Disease Dementia

Brain Sciences
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 1% of population over age 60. It is defined by motor and nonmotor symptoms including a spectrum of cognitive impairments known as Parkinson’s disease dementia (PDD ...
Emma D. Frost, Swanny X. Shi, Vishnu V. Byroju, Jamir Pitton Rissardo, Jack Donlon, Nicholas Vigilante, Briana P. Murray, Ian M. Walker, Andrew McGarry, Thomas N. Ferraro, Khalid A. Hanafy, Valentina Echeverria, Ludmil Mitrev, Mitchel A. Kling, Balaji Krishnaiah, David B. Lovejoy, Shafiqur Rahman, Trevor W. Stone, Maju Mathew Koola   +18 more
doaj   +1 more source

Lippia umbellata Cav.: Chemical Composition, Insecticidal, and Antimicrobial Activities

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Hexane extracts of Lippia umbellata leaves and flowers contain lupenone, α‐amyrin, and hentriacontane. They exhibit insecticidal activity against Drosophila melanogaster and inhibit AChE in vitro and in silico. Furthermore, the extracts can inhibit the growth of medically important bacteria and yeasts, including multidrug‐resistant strains.
José Guillermo Avila‐Acevedo, Miriam Arlette López‐Pérez, Ana Karen Villagómez‐Guzmán, Edgar Antonio Estrella‐Parra, Nallely Álvarez‐Santos, Israel Valencia‐Quiroz, Julieta Orozco‐Martínez, Ma. Edith López‐Villafranco, Silvia Aguilar‐Rodríguez, Carlos Leonardo Céspedes‐Acuña, Juio Alarcón‐Enos, Ana María García‐Bores   +11 more
wiley   +1 more source

Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In cardiovascular disease (CVD) patients, accelerated biological aging is independently associated with elevated mortality risk, which is mediated by neurodegenerative disease. Early‐onset CVD amplifies the mortality risk, whereas a healthy lifestyle confers partial protection.
Jinyue Li, Han Ma, Guohua Wang
wiley   +1 more source