Results 61 to 70 of about 9,994 (168)

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

Journal of Pharmacological Sciences, 2012
We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice.
Perrine Busquet, Valeria Capurro, Andrea Cavalli, Daniele Piomelli, Angelo Reggiani, Rosalia Bertorelli   +5 more
doaj   +1 more source

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE).
Azadeh Karami, Maria Eriksdotter, Maria Eriksdotter, Ahmadul Kadir, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Agneta Nordberg, Taher Darreh-Shori   +8 more
doaj   +1 more source

Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests: results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) Efeitos da galantamina sobre a memória e a atenção na doença de Alzheimer medidos por testes neuropsicológicos computadorizados: resultados do Estudo Multicêntrico com Galantamina (GAL-BRA-01)

Arquivos de Neuro-Psiquiatria, 2004
OBJECTIVE: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer's disease (AD) in a computerized neuropsychological test battery (CNTB).
Paulo Caramelli, Márcia L.F. Chaves, Eliasz Engelhardt, João Carlos B. Machado, Rodrigo R. Schultz, Francisco A.C. Vale, Helenice Charchat-Fichman   +6 more
doaj   +1 more source

Sleep and memory problems: acetylcholine in some neurodegenerative diseases, use of an extended-release formulation of galantamine

Неврология, нейропсихиатрия, психосоматика, 2012
The paper reviews the literature dedicated to an association between sleep and memory problems and acetylcholine (AC) levels. Moderate impairments of circadian rhythms can develop with aging; however, these changes become quite significant in dementia ...
I V Litvinenko
doaj   +1 more source

Clinically meaningful treatment responses after switching to galantamine and with addition of memantine in patients with Alzheimer’s disease receiving donepezil

Neuropsychiatric Disease and Treatment, 2013
Osamu Kano,1 Hirono Ito,1 Takanori Takazawa,1 Yuji Kawase,1 Kiyoko Murata,1 Konosuke Iwamoto,1 Tetsuro Nagaoka,1 Takehisa Hirayama,1 Ken Miura,1 Riya Nagata,1 Tetsuhito Kiyozuka,2 Jo Aoyagi,2 Ryuta Sato,2 Teruo Eguchi,3 Ken Ikeda,1 Yasuo ...
Kano O, Ito H, Takazawa T, Kawase Y, Murata K, Iwamoto K, Nagaoka T, Hirayama T, Miura K, Nagata R, Kiyozuka T, Aoyagi J, Sato R, Eguchi T, Ikeda K, Iwasaki Y   +15 more
doaj  

Acetylcholinesterase Inhibitor Ameliorates Early Cardiometabolic Disorders in Fructose-Overloaded Rat Offspring

Pharmaceuticals
Background: We investigate the role of galantamine on autonomic dysfunction associated with early cardiometabolic dysfunction in the offspring of fructose-overloaded rats.
Victor Hugo Martins de Miranda, Camila Paixão Dos Santos, Pietra Petrica Neves, Antonio Viana Nascimento-Filho, Marina Rascio Henriques Dutra, Nathalia Bernardes, Maria Claúdia Irigoyen, Kátia De Angelis   +7 more
doaj   +1 more source

Development of transfersomal buccal patches of galantamine for enhanced bioavailability in Alzheimer’s disease therapy

Journal of Applied Pharmaceutical Research
Background: Galantamine, an acetylcholinesterase inhibitor used in Alzheimer’s disease, exhibits low and variable bioavailability due to gastrointestinal metabolism and first-pass hepatic elimination. Buccal drug delivery offers a non-invasive route that
Pavuluri Chandrasekhar, Rajaganapathy Kaliyaperumal   +1 more
doaj   +1 more source

Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs

Molecules, 2017
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several pharmacological purposes.
Rona R. Ramsay, Keith F. Tipton
doaj   +1 more source

Feasibility Study of Nose-to-Brain Delivery of Galantamine for Alzheimer’s Disease: Enhancing Olfactory-Region Deposition to Improve Therapeutic Efficacy

Pharmaceutics
Background: Alzheimer’s disease (AD) is the seventh leading cause of death worldwide, posing a substantial global health burden. Although galantamine (GNT) is a first-line clinical drug for AD treatment, its therapeutic efficacy is constrained by ...
Chuangxin Chen, Chunying Leung, Zizhao Zhai, Guanlin Wang, Rui Yang, Qiuyi Hu, Xiao Yue, Zhongxuan Yao, Ziyu Zhao, Xuejuan Zhang   +9 more
doaj   +1 more source

Applications of snowdrop medicinal plant material in homeopathic pharmacy: a brief historical background and a systematic review of homeopathic medicines standardization

Сеченовский вестник, 2015
Currently, relevant studies are related to the development of private pharmacopeia articles with the requirements for medicinal plant raw materials and homeopathic mother tincture used in homeopathic practice. The article presents a brief overview of the
D. O. Bokov, I. A. Samylina
doaj