Results 61 to 70 of about 11,885 (204)
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda +10 more
wiley +1 more source
Brain CirculationBACKGROUND: Acetylcholinesterase inhibitors (AChEIs) are widely used in Alzheimer’s disease (AD). This study aims to systematically review the literature about movement disorders (MDs) associated with AChEIs for AD, which include donepezil, galantamine ...
Jamir Pitton Rissardo +1 more
doaj +1 more source
Additional file 1 of Galantamine ameliorates experimental pancreatitis
, 2023 Additional file 1: Figure S1. Galantamine decreases pancreatic pro-inflammatory cytokine production in acute pancreatitis. Galantamine administration reduces pancreatic (A) MCP-1 and (D) IL-1β but not (B) IL-10 or (C) TNFα.
Arvind Rishi (14956122) +9 more
core +1 more source
Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION The brain is a complex dynamical system, influenced by arousal state. Cortical synchrony supports information processing and is disrupted in Alzheimer's disease (AD). Locus coeruleus (LC) integrity and pupillometry index arousal system structure and function.
Michael C. B. David +12 more
wiley +1 more source
Galantamine-Memantine Combination in the Treatment of Parkinson’s Disease Dementia
Brain SciencesParkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 1% of population over age 60. It is defined by motor and nonmotor symptoms including a spectrum of cognitive impairments known as Parkinson’s disease dementia (PDD ...
Emma D. Frost +18 more
doaj +1 more source
, 2015 Melatonin is a neurohormone whose levels are significantly reduced or absent in Alzheimer's disease (AD) patients. In these patients, acetylcholinesterase inhibitors (AChEI) are the major drug class used for their treatment; however, they present ...
Negredo Madrigal, Pilar +6 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract BACKGROUND Remote, smartphone‐based cognitive testing may improve access to cognitive assessments for Alzheimer's disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone‐based cognitive tests in a registry‐based cohort.
Sreya Dhanam +18 more
wiley +1 more source
Behavioral analysis of 5XFAD-transgenic mice after treatment with galantamine.
, 2014 In the Open Field (A, B) galantamine treatment restored the preference for the corners (A) and the avoidance of the center (B). Non-transgenic mice receiving water (black columns) showed a significantly higher corner preference (**, p = 0.0045) and ...
Christin Haertel (525948) +3 more
core +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.Thiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Sandeep Bindra +11 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu +4 more
wiley +1 more source