Results 71 to 80 of about 11,885 (204)

Transcriptome Analysis and Metabolic Profiling of Lycoris Radiata

Biology, 2019
Lycoris radiata belongs to the Amaryllidaceae family and is a bulbous plant native to South Korea, China, and Japan. Galantamine, a representative alkaloid of Amaryllidaceae plants, including L.
Chang Ha Park, Hyeon Ji Yeo, Ye Eun Park, Seung-A Baek, Jae Kwang Kim, Sang Un Park   +5 more
doaj   +1 more source

Water consumption, galantamine uptake, and body weight of 5XFAD-transgenic mice treated with galantamine.

, 2014
Water consumption (A) of 5XFAD transgenic was similar irrespective of added galantamine (black triangles: water (n = 16); diamonds: high dose (n = 16), squares: low dose (n = 8).
Christin Haertel (525948), Soumee Bhattacharya (525947), Dirk Montag (106874), Alfred Maelicke (525949)   +3 more
core   +1 more source

Tramiprosate, the Active Agent of ALZ‐801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease

Drug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT ALZ‐801, a valine‐conjugated prodrug of tramiprosate, has recently been evaluated in a Phase III trial as a potential Alzheimer's disease (AD)‐modifying therapy. Tramiprosate reduces misfolding of amyloid beta (Aβ) monomers and inhibits oligomer formation. In the present study, we investigated tramiprosate's effects on amyloidogenic processing
Kevser Biberoglu, Ozden Tacal
wiley   +1 more source

The Effects of an Uninterrupted Switch from Donepezil to Galantamine without Dose Titration on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease

Dementia and Geriatric Cognitive Disorders Extra, 2014
Aims: To elucidate the efficacy of galantamine on cognition and behavioral and psychological symptoms of dementia (BPSD) in outpatients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) who have switched from donepezil to galantamine ...
Shoichi Sasaki, Yoshiharu Horie
doaj   +1 more source

Galantamine increases excitability of CA1 hippocampal pyramidal neurons

, 2006
Galantamine is a third generation cholinesterase inhibitor and an allosteric potentiating ligand of nicotinic acetylcholine receptors. It enhances learning in aging rabbits and alleviates cognitive deficits observed in patients with Alzheimer's disease ...
Power, J. M., Wu, W. W., Disterhoft, J. F., Oh, M. M.   +3 more
core   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source

Palladium-Catalyzed Synthesis, Acetylcholinesterase Inhibition, and Neuroprotective Activities of N‑Aryl Galantamine Analogues

, 2023
A series of new N-aryl galantamine analogues (5a–5x) were designed and synthesized by modification of galantamine, using Pd-catalyzed Buchwald–Hartwig cross-coupling reaction in good to excellent yields.
Xian-Li Zhou (2676346), Yang Zhang (30734), Wan-Sheng Ji, Yao Xiao, Xian-Li Zhou, Lin-Xi Wan, Yu Lei (266919), Lin-Xi Wan (10262561), Yu Lei, Yang Zhang, Feng Gao (3548), Yao Xiao (227567), Lian-Hai Shan (4603090), Feng Gao, Jin-Bu Xu (13267016), Lian-Hai Shan, Wan-Sheng Ji (14660582), Jin-Bu Xu   +17 more
core   +1 more source

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE).
Azadeh Karami, Maria Eriksdotter, Maria Eriksdotter, Ahmadul Kadir, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Agneta Nordberg, Taher Darreh-Shori   +8 more
doaj   +1 more source

DOMINO-AD protocol : donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT [PDF]

, 2009
Background: Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has
Ashley Baldwin, Ajay Macharouthu, Juszczak, E, R. Brown (3682735), Raftery, James, Jones Rob, Gray, R, Ballard, C, Burns, Alistair; id_orcid, Adams, Jessica, Knapp, M, Raftery James, J. Adams (7579901), Knapp, Martin, Griffin Mary, Ian McKeith, Baldwin, A, P. Passmore (7608800), Dening, Tom, Griffin, M, S. Banerjee (1503751), B. Sheehan (7608761), Jones Roy, Jones, Roy, T. Dening (7608776), Sube Banerjee, Sheehan, Bart, McShane, R, Patrick Phillips, Bentham, Peter, Findlay David, O'Brien, John, Alistair Burns, Barber, Bob, McShane, Rupert, Brown, R, Ritchie Craig, Dening, T, Hughes, Alan, J. Raftery (7608803), O'Brien John, Richard Brown, Holmes, C, Jessica Adams, Jacoby, Robin, Phillips, Patrick, McShane Rupert, Dening Tom, Clive Holmes, D. Findlay (7608779), Ballard Clive, Bart Sheehan, Rob Jones, Raftery, J, Brown, R. G., McKeith, I, Ritchie, C. W., A. Baldwin (7608767), Ritchie, Craig, P. Phillips (5239541), DOMINO-AD team, Banerjee, S, Ed Juszczak, P. Bentham (7589273), Juszczak, Ed, James. Lindesay (7608785), Robin Jacoby, Alan Hughes, Bob Barber, Richard Gray, Barber, B, Tony Johnson, Knapp Martin, Baldwin Ashley, Clive Ballard, Peter Bentham, Brown, Richard, McKeith, Ian, Brown, Richard; id_orcid, Juszczak Ed, Phillips Patrick, James Raftery, E. Juszczak (7589267), Burns, A, Howard Rob, Banerjee, Sube, Macharouthu, Ajay, Passmore, P, Brown Richard, Jones, R, Hughes Alan, Gray, Richard, Phillips, P, R. Jacoby (7589288), J. O'Brien (7608797), Phillips, P., Macharouthu Ajay, A. Burns (842688), R. Howard (1274091), Juszczak, Edmund, C. Holmes (7589285), Howard, Rob, M. Griffin (3933326), Macharouthu, A, M. Knapp (2534038), Jones, R. G., C. Ballard (7608770), Passmore, Peter, Johnson, T, Rob Howard, Holmes Clive, Sheehan Bart, Findlay, David, Rupert McShane, Jacoby, R, James Lindesay, Johnson, T., Hughes, A., Craig Ritchie, Howard, Robert, Jones, Roy W., O'Brien, J. T., David Findlay, R. McShane (7608791), Howard, R, Tom Dening, Onions Caroline, Holmes, Clive, McKeith Ian, Lindesay, J, Johnson Tony, Gray Richard, Barber Bob, I. McKeith (7608788), Ritchie, C, Burns Alistair, Adams, J., T. Johnson (7602368), A. Macharouthu (7608794), Johnson, Tony, Lindesay James, McKeith, I. G., A. Hughes (7190519), Jones, Rob, Banerjee Sube, Bentham Peter, Hughes, A, Lindesay, James, Raftery, J. P., Adams Jessica, Mary Griffin, Onions, Caroline, Griffin, Mary, C. Ritchie (7608806), Onions, C, Peter Passmore, John O'Brien, Baldwin, Ashley, Sheehan, B, Adams, J, Burns, Alistair, Jacoby Robin, Burns, Alistair S., Griffin, M., Passmore Peter, Roy Jones, R. Jones (3979994), Ballard, Clive, C. Onions (7608764), Bentham, P, Findlay, D, O'Brien, J, B. Barber (7608773), R. Gray (7608782), Martin Knapp, Caroline Onions   +175 more
core   +1 more source