Results 21 to 30 of about 11,885 (204)
Metabolites, 2021 Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich +4 more
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, 2022 Galantamine, like nor-belladine, is a benzazepine. Galanthus and other plants of the Amaryllidaceae are the most common sources of it. Galantamine is used to combat the muscle effects of gallamine triethiodide and tubocurarine by acting as a ...
Amar Pal Singh +9 more
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Clinicial and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review [PDF]
, 2001 Background Alzheimer’s disease is the most common cause of dementia and is characterised by an insidious onset and slow deterioration. The estimated prevalence of Alzheimer’s disease for a standard health authority (500,000 people) is about 3330. Current
A. Clegg +18 more
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Journal of Neuroinflammation, 2021 Background Binge ethanol exposure during adolescence reduces hippocampal neurogenesis, a reduction which persists throughout adulthood despite abstinence.
Victoria Macht +3 more
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Can we predict the response to Galantamine in Alzheimer`s disease patients? [PDF]
Romanian Journal of Neurology, 2015 Although considerate progress was obtained by adding imagistic and laboratory test, clinical examination remains the core of the diagnosis for Alzheimer`s disease. After 20 years of experience with anticholinergic drugs we know that only one third of the
Carmen Gavan +2 more
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Galantamine Effects on Memory, Spatial Cue Utilization, and Neurotrophic Factors in Aged Female Rats
Cell Transplantation, 2007 Galantamine is an acetylcholine esterase inhibitor that has been approved for use in Alzheimer's disease. However, even though clinical studies indicate efficacy in attenuating some of the symptoms associated with the disease, there are a paucity of ...
K. L. French +2 more
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Journal of Pharmacological Sciences, 2006 .: The cholinergic system undergoes changes with aging and in Alzheimer’s disease. The effects of the anticholinesterase drugs galantamine and donepezil were studied in a model with sodium nitrite-induced hypoxia in rats.
Dimitrova Darinka Slavcheva +1 more
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Antidiabetic Effect of Galantamine: Novel Effect for a Known Centrally Acting Drug.
PLoS ONE, 2015 The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate its ...
Mennatallah A Ali +3 more
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Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020 Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive efficacy compared to oral ...
Charlotte Bakker +7 more
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