Results 61 to 70 of about 12,328 (239)

Impact of Prior Biologic Mechanism of Action on Anti‐TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide ENEIDA registry study, anti‐TNF therapy after prior exposure to a different biologic mechanism of action showed reduced treatment durability in inflammatory bowel disease, with a particularly marked impact in ulcerative colitis, where short‐ and long‐term clinical effectiveness was also lower. ABSTRACT Background The expanding use of
Carmen Yagüe Caballero, Santiago García López, Ana Royo Esteban, Laura Figueras Panillo, Pilar Nos, Luisa de Castro, M. Dolores Martín‐Arranz, Manuel Barreiro‐de Acosta, Elena Ricart, Ruth de Francisco, Eva Iglesias, Antonio Giordano, Pilar Varela, Iago Rodríguez‐Lago, Montserrat Rivero, Beatriz Sicilia, Merce Navarro‐Llavat, Isabel Vera, Carles Suria, Jordi Guardiola, Jesús Barrio, Margalida Calafat, Ana Gutiérrez, Xavier Calvet, David Rafael de la Cruz, Francisco Mesonero, Cristina Martínez Pascual, Javier P. Gisbert, Carla J. Gargallo‐Puyuelo, David Monfort i Miquel, Mónica Sierra, Laura Arranz, Cristina Rodríguez‐Gutiérrez, Rufo Lorente, Fernando Bermejo, Lucía Márquez‐Mosquera, Gisela Torres Vicente, José Lázaro Pérez‐Calle, José M. Huguet, Laura Ramos, Ángel Ponferrada‐Díaz, Daniel Ceballos, Mª. Teresa Diz‐Lois Palomares, Eva Sesé Abizanda, Pablo Vega, Ramón Pajares, Javier Santos Fernández, Elena Betoré, David Busquets, Olga Merino, Carlos Martínez‐Flores, Yamile Zabana, Manuela Josefa Sampedro González, Jone Ortiz de Zarate, Ana Fuentes Coronel, Empar Sainz Arnau, Daniel Carpio, Nuria Jiménez, Ignacio Marín‐Jiménez, Luis Bujanda, Raquel Camargo Camero, Martín Irabien, María Abanades Tercero, Benito Velayos Jiménez, Pilar Robledo Andres, Ana María Trapero, Pedro G. Delgado‐Guillena, Luís Hernández Villalba, Margarita Menacho, Nuria Rull Murillo, Carles Leal, Cristina Alba, Rosa Gómez Espín, Alfredo J. Lucendo, Manuel Van Domselaar, Laura García Alles, Eduardo Iyo Miyashiro, Ana Crespo Catalá, Pau Gilabert, Daniel Martín Rodríguez, Víctor Manuel Navas‐López, María Calvo Iñiguez, Daniel Ginard, Teresa Martínez Pérez, Eugeni Domènech, Diego Casas Deza   +85 more
wiley   +1 more source

Dynamic Downscaling of the Impact of Climate Change on the Ocean Circulation in the Galápagos Archipelago

Advances in Meteorology, 2013
The regional impact of global climate change on the ocean circulation around the Galápagos Archipelago is studied using the Hybrid Coordinate Ocean Model (HYCOM) configured for a four-level nested domain system.
Yanyun Liu, Lian Xie, John M. Morrison, Daniel Kamykowski   +3 more
doaj   +1 more source

Health assessment of Galapagos pinniped pups during the 2024 El Niño event: hematological, biochemical, and morphometric findings [PDF]

Veterinary World
Background and Aim: The Galapagos sea lion (Zalophus wollebaeki) and Galapagos fur seal (GFS; Arctocephalus galapagoensis) are endemic pinnipeds highly vulnerable to environmental fluctuations associated with the El Niño–Southern Oscillation (ENSO). This
Eduardo A. Díaz, Andrés Moreira-Mendieta, Carolina Sáenz, Andrea Loyola, Jenifer Suárez-Moncada, Daniel García-Párraga, Pablo Jesús Marín-García, Marjorie Riofrío-Lazo, Diego Páez-Rosas   +8 more
doaj   +1 more source

Effects of chronic lymphocytic leukaemia (CLL)‐directed therapy on diffuse large B‐cell lymphoma (DLBCL) type Richter transformation compared to de novo DLBCL in a nationwide cohort

British Journal of Haematology, EarlyView.
Summary Diffuse large B‐cell lymphoma (DLBCL) type Richter transformation (DLBCL‐RT) in patients with chronic lymphocytic leukaemia (CLL) has a worse prognosis compared to de novo DLBCL (dnDLBCL). We investigated outcomes of patients with DLBCL‐RT with or without previous CLL‐directed therapy compared to dnDLBCL between 2002 and 2022.
Andreas Katsimigas, Mikkel Werling, Casper M. Frederiksen, Noomi Vainer, Klaus Rostgaard, Yasmin Ben‐Dali, Mariam H. Hleuhel, Christian Brieghel, Carsten U. Niemann, Caspar da Cunha‐Bang   +9 more
wiley   +1 more source

Haemosporidian parasite community in migrating bobolinks on the Galapagos Islands

International Journal for Parasitology: Parasites and Wildlife, 2018
Bobolinks (Dolichonyx oryzivorus) migrate from their breeding grounds in North America to their wintering grounds in South America during the fall each year. A small number of Bobolinks stop temporarily in Galapagos, and potentially carry parasites.
Noah G. Perlut, Patricia G. Parker, Rosalind B. Renfrew, Maricruz Jaramillo   +3 more
doaj   +1 more source

Glofitamab in combination with immunochemotherapy in patients with relapsed/refractory B‐cell non‐Hodgkin lymphoma: Phase 1b dose‐escalation study

British Journal of Haematology, EarlyView.
Summary Glofitamab was investigated with obinutuzumab/rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (G/R‐CHOP) in patients with relapsed/refractory B‐cell non‐Hodgkin lymphoma (B‐NHL) who had ≥1 prior obinutuzumab/rituximab‐containing therapy (NCT03467373). The primary end‐point was to determine the optimal biological dose of
William Townsend, Nilanjan Ghosh, Martin Hutchings, Michael Dickinson, Monica Tani, Armando Santoro, Michael Crump, Amitkumar Mehta, Reinhard Marks, Martin Weisser, Martin Barrett, Chun Wu, Derrick Kaufman, Katharina Lechner, Pauline Baumlin, Pontus Lundberg, Max S. Topp   +16 more
wiley   +1 more source

Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling

Drugs in R&D
Background and Objective This study provides a physiologically based pharmacokinetic (PBPK) model-based analysis of the potential drug–drug interaction (DDI) between cyclosporin A (CsA), a breast cancer resistance protein transporter (BCRP) inhibitor ...
Stephan Schaller, Ingrid Michon, Vanessa Baier, Frederico Severino Martins, Patrick Nolain, Amit Taneja   +5 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Evolutionary framework and tribal circumscription of Amaranthaceae sensu stricto based on a comprehensive phylogenomic analysis

Cladistics, EarlyView.
Abstract The evolutionary history of Amaranthaceae sensu stricto (s.s.) has been shaped by multiple whole‐genome duplications and rapid radiations, producing an ecologically diverse lineage whose internal relationships have long remained unresolved.
Tina Kiedaisch, Anže Žerdoner Čalasan, Ross A. McCauley, Gudrun Kadereit   +3 more
wiley   +1 more source

Quick assessment of quality‐of‐life in itch: An exploratory validation of the 5‐item pruritus life quality

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) significantly impairs quality of life (QoL), but existing patient‐reported QoL tools are either not specific for CP or are very extensive. Patients and methods The 5‐item pruritus life quality (5PLQ, range: 5–25, 7‐day recall) was developed to assess key itch‐related QoL domains (sensory symptoms,
Claudia Zeidler, Simone Garcovich, Svetlana Bobko, Franz J. Legat, Andrey Lvov, Emilie Brenaut, Adam Reich, Esther Serra‐Baldrich, Laurent Misery, Jacek C. Szepietowski, Martin Dugas, Felix Aulenbacher, Pascale Salameh, Sonja Ständer, Manuel P. Pereira   +14 more
wiley   +1 more source