Results 11 to 20 of about 7,808,989 (241)
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Chemical and kinematical evolution in nearby dwarf spheroidal galaxies [PDF]
, 2006 Dwarf spheroidal (dSph) galaxies are the least massive and luminous objects known to exist. These galaxies are often considered as the fossil building blocks of massive systems predicted by some cosmological models.
Koch, Andreas
core +1 more source
High-redshift Dusty Star-Forming Galaxies: a panchromatic approach to constrain massive galaxy evolution [PDF]
, 2021 The goal of this thesis is to investigate the early stages of massive galaxy evolution by defining an overall view of their physical properties combining the information extracted by all the details of their spectral behaviour.
Pantoni, Lara
core
On the origin and evolution of life in the Galaxy [PDF]
, 2010 A simple stochastic model for evolution, based upon the need to pass a sequence of n critical steps is applied to both terrestrial and extraterrestrial origins of life. In the former case, the time at which humans have emerged during the habitable period
McCabe, Michael +3 more
core +1 more source
Secondary evolution of galaxies investigated by N-body simulations [PDF]
, 2008 In the ΛCDM cosmology, merging is one of the most important physical processes that drives the formation and evolution of galaxies. In the present work, we use N-body techniques to investigate some of currently open issues related to the formation and ...
Coppola, Giuseppina
core +1 more source
The Astrophysical JournalWe present an empirical chemical evolution model that explains the distribution of metals in the interstellar medium (ISM) and the circumgalactic medium (CGM) of galaxies based on the U niverse M achine and N eutral U niverse M achine models in the ...
Moka Nishigaki +7 more
doaj +1 more source
A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science
Advanced Engineering Materials, EarlyView.We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann +8 more
wiley +1 more source
The Astrophysical JournalGas-phase metallicity gradients are a crucial element in understanding the chemical evolution of galaxies. We use the FOGGIE simulations to study the metallicity gradients (∇ Z ) of six Milky Way–like galaxies throughout their evolution.
Ayan Acharyya +9 more
doaj +1 more source
On the α/Fe Bimodality of the M31 Disks
The Astrophysical Journal Letters, 2023 An outstanding question is whether the α /Fe bimodality exists in disk galaxies other than in the Milky Way. Here we present a bimodality using our state-of-the-art galactic chemical evolution models that can explain various observations in the Andromeda
Chiaki Kobayashi +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk +11 more
wiley +1 more source