Results 141 to 150 of about 113,439,941 (280)

Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin‑3 over Galectin‑1

, 2016
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine–arene ...
Ed E. Moret (1822108), Hilbert M. Branderhorst (1992469), Hakon Leffler (200845), Roland J. Pieters (154119), Ulf J. Nilsson (831832), Hilde van Hattum (1992466)   +5 more
core   +1 more source

Identifying regulatory muscle processes in infantile and adult Pompe patients using a multi‐omic and morphological approach

Brain Pathology, EarlyView.
The study highlights differences in the regulatory processes of skeletal muscle, such as sarcomeric contractility, lysosomal and autophagic function, metabolic activity and immune regulation, at transcriptomic and proteomic levels in infantile and adult Pompe disease.
Alexander Schaiter, Keerthika Lohanadan, Alexander Mensch, Andreas Hentschel, Angela Rosenbohm, Cornelia Kornblum, Angela Roth, Tara Procida‐Kowalski, Heidrun H. Krämer, Andreas Hahn, Jörg Höhfeld, Dieter O. Fürst, Werner Stenzel, Peter F. M. van der Ven, Andreas Roos, Marek Bartkuhn, Anne Schänzer   +16 more
wiley   +1 more source

The role of galectins in modulating the tumor microenvironment and driving metastasis in skin cancers

Biological Research
Galectins, a family of β-galactoside–binding lectins, are key regulators of tumor progression, immune evasion, and therapy resistance in skin cancers. Among them, Galectin-1, Galectin-3, and Galectin-9 have been most extensively investigated for their ...
Mohsen Dabagh, Alina Ciceu, Cornel Balta, Maria Consiglia Trotta, Bartolo Ferraro, Giovanbattista D’Amico, Anca Hermenean, Vlad Mihail Voiculescu   +7 more
doaj   +1 more source

Protective role of Galectin‐3 in prion disease through regulation of microglial PrPSc uptake

Brain Pathology, EarlyView.
Galectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Natallia Makarava, Tarek Safadi, Narayan P. Pandit, Olga Mychko, Olga Bocharova, Alexey Shevelkin, Kara Molesworth, Marta M. Lipinski, Ilia V. Baskakov   +8 more
wiley   +1 more source

Galectin-1 [PDF]

, 2020
openaire   +1 more source

C1-Galactopyranosyl Heterocycle Structure Guides Selectivity: Triazoles Prefer Galectin‑1 and Oxazoles Prefer Galectin‑3

ACS Omega, 2019
Alexander Dahlqvist, Hakon Leffler, Ulf J. Nilsson   +2 more
doaj   +1 more source

An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor

Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments.
Wachenfeldt, Henrik von, Diehl, Carl, Roper, James A., Zetterberg, Fredrik R., Slack, Robert J., Klein, Hanna, Nilsson, Ulf J., Håkansson, Maria, Pedersen, Anders, MacKinnon, Alison C., Peterson, Kristoffer, Kahl-Knutson, Barbro, Leffler, Hakon, Pedersen, Anders,, Diehl, Carl,, Klein, Hanna,, Roper, James A.,, Nilsson, Ulf J.,, Håkansson, Maria,, Wachenfeldt, Henrik von,, Kahl-Knutson, Barbro,, Zetterberg, Fredrik R.,, Peterson, Kristoffer,, Slack, Robert J.,, MacKinnon, Alison C.,, Lund University., Leffler, Hakon,   +26 more
core   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Complement–Eosinophil Crosstalk Links Complement Activation to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis

Allergy, EarlyView.
Ryo Hasegawa, Shigeharu Ueki, Misaki Arima, Shohei Nishiyama, Keinosuke Hizuka, Kohei Tatsumi, Ayako Sawai, Anna Shimizu, Yuki Sonoda, Eiichi Kato, Masanori Kidoguchi, Masafumi Sakashita, Yohei Sato, Atsushi Kato, Bruce K. Tan, Robert C. Kern, Robert P. Schleimer, Shigeharu Fujieda, Yoshimasa Imoto   +18 more
wiley   +1 more source