Results 121 to 130 of about 113,439,941 (280)

Galectin-3 promotes EV71 infection.

, 2016
(A) Using TALEN, ablation of the galectin-3 gene was performed in RD cells. Two clones of galectin-3 knock-out (G3KO) RD cells were selected. Protein expression of galectin-3 was examined in cell lysates from RD cells and two G3KO clones (G3KO-A1 and ...
Yungling Lee (3454598), Fu-Tong Liu (30764), Li-Min Huang (185153), Wen-Chan Huang (3597764), Hung-Lin Chen (172758), Kuan-Po Peng (3597767), Huan-Yuan Chen (3597761), Luan-Yin Chang (185145)   +7 more
core   +1 more source

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome

PROTEOMICS, EarlyView.
ABSTRACT Disease‐related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin.
Sinja Buchner, Sihui Song, Stephan A. Müller, Yun Chen, Samira Parhizkar, Stefan F. Lichtenthaler, David M. Holtzman, Mathias Jucker, Stephan A. Kaeser   +8 more
wiley   +1 more source

Galectin-1 and galectin-3 in chronic pancreatitis.

, 2000
Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined
Zimmermann A, Zhu Z, Büchler MW, Friess H, Berberat PO, Frigeri L, Korc M, Wang L   +7 more
core   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Host‐induced silencing of the Minc09294 effector gene impairs Meloidogyne incognita and M. Enterolobii infection

Pest Management Science, EarlyView.
Host‐induced gene silencing of the effector candidate Minc09294 significantly impairs Meloidogyne incognita parasitism, markedly reducing gall formation, reproduction, and the development of specialized giant cells, with partial cross‐species effects on M.
João Pedro Abreu‐Sousa, Thuanne Pires Ribeiro, Daniele Heloisa Pinheiro, Valdeir Junio Vaz Moreira, Luanna Pinheiro Alburquerque Freitas Bezerra, Júlia Moura Rosário Santana, Lays Antunes Teixeira, Maria Eugenia Lisei‐de‐Sa, Deyse Alexandra Rosero Alpala, Manoely Abreu Reis, Isabela Tristan Lourenço‐Tessutti, Leonardo Lima Pepino Macedo, Carolina Vianna Morgante, Maria Cristina Mattar Silva, Marcos Fernando Basso, Janice de Almeida‐Engler, Maria Fatima Grossi‐de‐Sa   +16 more
wiley   +1 more source

The Role of Galectin-3 in Th17 Differentiation

, 2010
第十七型輔助型T細胞 (T helper 17 cells, Th17 cells)，一個最近被大量研究的輔助型T細胞分支，在病理上被認為是導致自體免疫疾病的主要原因之一。在Th17的細胞分化以及生理作用上,之前研究中已提供許多方面深入的探討。然而在Th17細胞之負向調控機制上，則相對的較缺乏清楚的了解並且仍需要更多的研究。 在此研究中我們發現，與野生控制組相比，Galectin-3基因剔除之輔助型T細胞於體外分化時較容易且大量的分化至Th17細胞，伴隨著主要分泌之細胞激素( IL-17, IL-21 )
朱安翔, Chu, An-Hsiang
core  

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

, 2008
The galectin family of lectins regulates multiple biologic functions, such as development, inflammation, immunity, and cancer. One common function of several galectins is the ability to trigger T cell death.
Shuguang Bi, Baum, Linda G, Linsey Jacobs, Linda G. Baum, Bi, Shuguang, Lesley A. Earl, Jacobs, Linsey, Earl, Lesley A   +7 more
core   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity

Molecular Therapy: Oncology
Chronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells.
John F. Imbery, Celina Wiik, Julia Heinzelbecker, Jenny K. Jebsen, Mia K. Dobbing, Nunzio Bottini, Stephanie M. Stanford, Ludvig A. Munthe, Geir E. Tjønnfjord, Anders Tveita, Peter Szodoray, Britt Nakken   +11 more
doaj   +1 more source

Immunofluorescent staining of galectin-1, -3 and -9.

, 2015
Representative triple staining image in an FFPE squamous cervical cancer sample containing tumor epithelial cells expressing galectin-1 (A, blue), galectin-3 (B, green) and galectin-9 (C, red) at a 200x magnification.
Victor L. Thijssen (635369), Ekaterina S. Jordanova (160493), Johannes Vrolijk (754218), Arko Gorter (24914), Cornelis D. de Kroon (754219), Simone Punt (754217)   +5 more
core   +1 more source