Results 131 to 140 of about 21,276,578 (296)
The Role of Galectin-3 in Th17 Differentiation
, 2010 第十七型輔助型T細胞 (T helper 17 cells, Th17 cells)，一個最近被大量研究的輔助型T細胞分支，在病理上被認為是導致自體免疫疾病的主要原因之一。在Th17的細胞分化以及生理作用上,之前研究中已提供許多方面深入的探討。然而在Th17細胞之負向調控機制上，則相對的較缺乏清楚的了解並且仍需要更多的研究。 在此研究中我們發現，與野生控制組相比，Galectin-3基因剔除之輔助型T細胞於體外分化時較容易且大量的分化至Th17細胞，伴隨著主要分泌之細胞激素( IL-17, IL-21 )
朱安翔, Chu, An-Hsiang
core
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source
Human multi-tissue transcriptomics identifies galectin-1 and follistatin-like 1 as exerkines with distinct transcript-to-serum coupling after exercise. [PDF]
J PhysiolAbstract figure legend Acute aerobic exercise induces LGALS1, FSTL1, OGN and C1QTNF3 in both skeletal muscle and adipose tissue, with LGALS1 and FSTL1 upregulation corresponding to increased circulating galectin‐1 and follistain‐like 1. Red and yellow brick bars represent the contribution of skeletal muscle and adipose tissue, respectively, integrating
Song J +5 more
europepmc +2 more sources
galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas
, 1999 Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of ...
Benvenuto G +9 more
core +1 more source
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1
Scientific ReportsThe role of glycan-binding proteins as an activator of immune regulatory receptors has gained attention recently. We report that galectin 7 reduced CD4+ T cell percentage in both in vitro culture and mouse tumor models.
Guojin Wu +4 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh +7 more
wiley +1 more source
Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis
, 2007 Inflammation of the subarachnoid and ventricular space contributes to the development of brain damage i.e. cortical necrosis and hippocampal apoptosis in pneumococcal meningitis (PM).
Bellac, Caroline L +9 more
core +1 more source
Allergy, EarlyView.IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama +16 more
wiley +1 more source
Histology and histopathology, 1997 The display of cellular oligosaccharide chains is known to undergo marked developmental changes, as monitored histochemically with plant lectins. In conjunction with endogenous lectins respective ligand structures may have a functional role during fetal development. The assumption of a recognitive, functionally productive interplay prompts the study of
Kaltner, H. +5 more
openaire +2 more sources