Results 131 to 140 of about 113,439,941 (280)
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
, 2018 Introduction: This study investigates the clinical significance of galectin-1 expression in carcinoma tissues, plasma, and lymphocytes of patients with clear-cell renal cell carcinoma (RCC).Methods: Galectin-1 expression was investigated, using ...
Changfu Li +6 more
core +1 more source
Histology and histopathology, 1997 The display of cellular oligosaccharide chains is known to undergo marked developmental changes, as monitored histochemically with plant lectins. In conjunction with endogenous lectins respective ligand structures may have a functional role during fetal development. The assumption of a recognitive, functionally productive interplay prompts the study of
Kaltner, H. +5 more
openaire +2 more sources
, 2013 Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at the thiodigalactoside C3 by CuAAC, targeting arginine-arene ...
Branderhorst, Hilbert M. +8 more
core +1 more source
Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures
Allergy, EarlyView.This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally +6 more
wiley +1 more source
Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1
Scientific ReportsThe role of glycan-binding proteins as an activator of immune regulatory receptors has gained attention recently. We report that galectin 7 reduced CD4+ T cell percentage in both in vitro culture and mouse tumor models.
Guojin Wu +4 more
doaj +1 more source
Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma
Allergy, EarlyView.This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez +14 more
wiley +1 more source
Expression of Galectin-1 and Galectin-3 in Human Fetal Thyroid Gland
, 2003 High levels of expression of galectin-1 and galectin-3, the β-galactoside-binding proteins, have been recently described in malignant thyroid tumors but not in adenomas nor in normal thyroid tissue.
Dubravka S. Cvejić +2 more
core +1 more source
Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth
Allergy, EarlyView.Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low +15 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source