Results 161 to 170 of about 43,144 (243)

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, Volume 183, Issue 7, Page 1502-1516, April 2026.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5‐Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT The IL‐33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL‐33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation; however, the role of IL‐33‐driven mast cell responses in helminth infection is poorly understood.
Nicole W. P. Ong, Suzanne H. Hodge, Christa P. Baker, Danielle J. Smyth, Tania Frangova, Henry J. McSorley   +5 more
wiley   +1 more source

Galectin-1 Inhibitor OTX008 [PDF]

, 2020
openaire   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Galectin-1: the decision maker [PDF]

Nature Reviews Immunology, 2008
openaire   +1 more source

Role of Galectin-1 in the Pathogenesis of Melanoma. [PDF]

J Cancer Sci Clin Ther
Kim G, Blackwell T, Banai K, Lin R, Chung J, Agrawal DK.   +5 more
europepmc   +1 more source

Galectin-1 Is a Marker but Not a Mediator of Heart Failure With Preserved Ejection Fraction. [PDF]

Hypertension
Wassenaar JW, Smart CD, Fehrenbach DJ, Shuey MM, Sangowdar P, Zhong L, Miller FJ, Wells QS, Huang S, Collins SP, Storrow AB, Miller KF, Gupta DK, Doran AC, Madhur MS.   +14 more
europepmc   +1 more source

Organoruthenium Glycomimetics Exhibit High Selectivity and Nanomolar Affinity for Human Galectin-1. [PDF]

J Med Chem
Hamala V, Kurfiřt M, Červenková Št́astná L, Dvořák F, Bernášková J, Sýkorová A, Kozák J, Zavřel M, Staroňová T, Šebest P, Ostatná V, Červený J, Bojarová P, Holčáková J, Hrstka T, Hrstka R, Karban J.   +16 more
europepmc   +1 more source