Results 171 to 180 of about 42,532 (255)

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Evaluation of the diagnostic utility of galectin-1 and TROP-2 in thyroid tumors: A retrospective analysis. [PDF]

Qatar Med J
Al-Kaabi MM, Al-Hindawi MM, Hasan IA.
europepmc   +1 more source

Design of galectin-1-conjugated nanoparticles as potential immunomodulatory agents. [PDF]

RSC Med Chem
Ghosh C, Yao L, Sigler M, Di Lella S, Cagnoni AJ, Rabinovich GA, Seeberger PH.   +6 more
europepmc   +1 more source

Fluorophore Modulates Intracellular Distribution of Enzyme‐Instructed Self‐Assembly of Short Peptides in Osteosarcoma Cells

Small Methods, Volume 10, Issue 3, 9 February 2026.
Fluorophores at the peptide C‐terminus reprogram EISA behavior in osteosarcoma cellsshifting ER vs mitochondrial targeting, altering assembly, and tuning cytotoxicity. Abstract Enzyme‐instructed self‐assembly (EISA) of peptides offers a versatile strategy for developing intracellular nanomedicines, yet the role of C‐terminus fluorophores in modulating ...
Yali Huang, Meihui Yi, Yuchen Qiao, Bing Xu   +3 more
wiley   +1 more source

Serum Galectin-1 as a Diagnostic Biomarker in Endometriosis: A Prospective Longitudinal Study. [PDF]

Int J Mol Sci
Brubel R, Balogh DB, Polgar B, Szereday L, Hudelist G, Acs N, Bokor A.   +6 more
europepmc   +1 more source

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

VIEW, Volume 7, Issue 1, February 2026.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi, B. W. M. Thilini J. Basnayake, Omar Breik, Lizbeth Kenny, Sarju Vasani, Riccardo Dolcetti, Chamindie Punyadeera   +6 more
wiley   +1 more source

miR-22-Galectin-1 as an integral signaling axis in regulating metabolism and immunity in HCC. [PDF]

Biomark Res
Hu Y, Setayesh T, Jena PK, Ji Y, Testerman T, Liu R, Shih TC, Wang XJ, Liu FT, Lam KS, Wan YY.   +10 more
europepmc   +1 more source

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Aging Cell, Volume 25, Issue 2, February 2026.
Young multipotent muscle‐derived stem/progenitor cells (MDSPCs) secrete a unique profile of pro‐angiogenic and immunomodulatory proteins that are diminished with age. Systemic transplantation of young MDSPCs into naturally aged mice activates pathways in neuromuscular tissues, enhancing health and driving molecular, structural, and functional ...
Seth D. Thompson, Chelsea L. Rugel, Maddlyn R. Haller, Jodi L. Curtin, Sudarshan Dayanidhi, Mitra Lavasani   +5 more
wiley   +1 more source

Production of functional human galectin-1 in transplastomic tobacco and simplified recovery via batch-mode purification. [PDF]

Front Plant Sci
Vater CF, Pérez Sáez JM, Stupirski JC, Massaro M, Mirkin FG, Bravo-Almonacid FF, Rabinovich GA, Morgenfeld MM.   +7 more
europepmc   +1 more source