Results 191 to 200 of about 113,439,941 (280)

Push–pull hypothesis of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract The “push–pull” hypothesis of Alzheimer's disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia, promoting the collapse of proteostasis, reducing tau degradation, and facilitating the cell‐to ...
Matthew Townsend
wiley   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Gastric cancer-secreted galectin-1 promotes peritoneal mesothelial-mesenchymal transition to prime peritoneal metastasis soil. [PDF]

iScience
Huang C, Jiang Z, Shen X, Ding Q, Wang H, Cheng Z, Liu G, Zhao X, You X.   +8 more
europepmc   +1 more source

Ventricular and Choroid Plexus Morphological Alterations and Their Associations With Peripheral Biomarkers in Behavioral Variant Frontotemporal Dementia

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Background Frontotemporal dementia (FTD) is a neurodegenerative disorder and a major cause of early‐onset dementia. Alterations in ventricular and choroid plexus volumes have been reported in several neurodegenerative diseases. The morphological alterations of the ventricular system and choroid plexus in behavioral variant frontotemporal ...
Ailing Yue, Qianqian He, Hua Lu, Yufei Chen, Jiahui Hou, Yuxuan Xu, Liyong Wu, Min Chu   +7 more
wiley   +1 more source

Human multi-tissue transcriptomics identifies galectin-1 and follistatin-like 1 as exerkines with distinct transcript-to-serum coupling after exercise. [PDF]

J Physiol
Song J, Cho ES, Kwon YR, Park JS, Nam JS, Kim Y.   +5 more
europepmc   +1 more source

Mechanistic Study of GSDME and CXCL10 in SUV39H1‐Mediated Pyroptosis and Immune Suppression in Cervical Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Cervical cancer (CC) remains a major global health challenge characterized by high incidence and mortality. The histone methyltransferase suppressor of variegation 3–9 homolog 1 (SUV39H1) has emerged as a key epigenetic regulator in tumor progression, but its role in modulating pyroptosis and remodeling of the immune microenvironment in CC ...
Li Zhang, Peiting Sheng, Dongge Cai, Ziyue Zhao, Xiaoling Wu, Yan'e Gao   +5 more
wiley   +1 more source

Expression and significance of PIBF combined with Galectin-1 in cervical precancerous lesions. [PDF]

Front Med (Lausanne)
Wang H.
europepmc   +1 more source

Compressive Goiter Hiding Clear Cell Renal Cell Carcinoma Metastases to the Thyroid Gland—Report of a Rare Case and Literature Review

Clinical Case Reports, Volume 14, Issue 11, November 2026.
Histological section (hematoxylin and eosin, 40× magnification) of the total thyroidectomy specimen showing the presence of characteristic compact nests and cellular sheets with clear or eosinophilic cytoplasm, diagnostic for secondary involvement of the thyroid gland by clear cell renal cell carcinoma.
Chuyao Ying, Henrique Messias, Carlos Zagalo, Saudade André, Pedro Gomes   +4 more
wiley   +1 more source

Design of galectin-1-conjugated nanoparticles as potential immunomodulatory agents. [PDF]

RSC Med Chem
Ghosh C, Yao L, Sigler M, Di Lella S, Cagnoni AJ, Rabinovich GA, Seeberger PH.   +6 more
europepmc   +1 more source

Right Ventricular Dysfunction and Ventriculo‐Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype‐Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies

Clinical Cardiology, Volume 49, Issue 11, November 2026.
Right ventricular dysfunction affects 19%–33% of patients With heart failure With preserved ejection fraction and is associated With exercise intolerance, hospitalization, and mortality. Assessing right ventricular function and its coupling with the pulmonary circulation may improve risk stratification and support management tailored to distinct ...
Amarelle Chamoun, Talha Farooq, Suhayya Batool, Sadia Tameez‐ud—din, Muhammad Yousaf, Preet Memon, Mohsin Ali, Arun Kumar Maloth, F. N. U. Sawaira, Muhammad Taimur Khan, Mohammad Eisa Ali, Mansoor Khalid, Maleeha Pandit, Kamil Ahmad Kamil   +13 more
wiley   +1 more source