Results 181 to 190 of about 42,532 (255)

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Differential Expression of Galectin-1 and Galectin-9 in Immune-Mediated Inflammatory Diseases. [PDF]

Int J Mol Sci
Valero-Martínez C, Pardines-Ortiz M, Montes N, Dauden E, Fernández-Gutierrez B, García-Planella E, Gomollón García F, Gratacós J, Pérez-Venegas JJ, Julía A, Marsal S, Lamana A, García-Vicuña R, González-Alvaro I, Triguero-Martínez A.   +14 more
europepmc   +1 more source

Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1–induced cell aggregation [PDF]

International Journal of Cancer, 2000
Nicola Tinari, Ichiro Kuwabara, Margaret E. Huflejt, Patrick F. Shen, Stefano Iacobelli, Fu-Tong Liu   +5 more
openaire   +1 more source

Endogenous Galectin-1 and Acute Inflammation [PDF]

The American Journal of Pathology, 2011
Asif J. Iqbal, André L.F. Sampaio, Francesco Maione, Karin V. Greco, Toshiro Niki, Mitsuomi Hirashima, Mauro Perretti, Dianne Cooper   +7 more
openaire   +1 more source

Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF‐κB/IL‐6/STAT3 Signalling Cascade

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT High mobility group box 1 (HMGB1), a prototypical alarmin and chromatin‐binding protein, has emerged as a critical mediator of tumour‐associated inflammation and immune regulation. Although its soluble form has been implicated in various malignancies, the functional contribution of HMGB1 encapsulated within exosomes remains incompletely ...
Jia‐Ru Huang, Wen‐Chao Gu, Ya‐Ping Yuan, Jun‐Xia Yang, Yan Chen, Xiao‐Xia Guo, Wei Ding   +6 more
wiley   +1 more source

Maternal Serum Galectin-1 in the First Trimester as a Potential Biomarker for Early Prediction of Pre-Eclampsia: A Prospective Study. [PDF]

Med Sci Monit
Yang Z, Li M, Deng C, Huang C, Wu L.
europepmc   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 310-320, February 2026.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Evaluation of Pathogenic Variants Associated With Monogenic Disorders of Dyslipidemia in Patients With Well Characterised MASLD

Liver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background and Aims Dyslipidemia is common in patients with MASLD, but the frequency and significance of inherited disorders of dyslipidemia are unclear. We investigated the prevalence and significance of pathogenic variants associated with selected monogenic disorders of dyslipidemia in 3358 patients with well‐characterised MASLD. Approach We
Tae‐Hwi Schwantes‐An, Marco A. Abreu, Brent A. Neuschwander‐Tetri, Jian Wang, Xiuqing Guo, Jingyi Tan, Robert A. Hegele, Nicholas O. Davidson, Luca Lotta, Niek Verweij, Katherine P. Yates, Jerome I. Rotter, Naga Chalasani   +12 more
wiley   +1 more source

A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy [PDF]

, 2018
Allavena, Giulia, Debellis, Doriana, Grimaldi, Benedetto, Joshi, Chetanchandra S, Marotta, Roberto, Mysorekar, Indira U   +5 more
core   +1 more source

HLA‐DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate‐Pulsing

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT The anti‐tumour immune response plays a pivotal role in eliminating tumour cells, with the presence of tumour‐infiltrating lymphocytes (TILs) often correlated with improved patient outcomes. Among these, CD4+ T lymphocytes act as key orchestrators of the immune response, functioning as effector and regulatory cells, and are essential for ...
Gonzalo Lázaro, Juan A. Cedano, Maitane Faus, Carme Roura‐Mir, Laia Garrigós, José Pérez‐García, Javier Román‐García, Javier Cortés, Andrea Aran, Mercè Martí   +9 more
wiley   +1 more source