Results 71 to 80 of about 43,144 (243)

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Galectin-3. One molecule for an alphabet of diseases, from A to Z [PDF]

, 2018
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation.
Bellotti, Carlo, De Francesco, Gian Paolo, Lavra, Luca, Magi, Fiorenza, Morgante, Alessandra, Ricci, Alberto, Salehi, Leila B., Sciacchitano, Salvatore, Ulivieri, Alessandra   +8 more
core   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility

Stem Cell Research & Therapy, 2017
Background Mesenchymal stromal cells (MSCs) can be used intra-articularly to quell inflammation and promote cartilage healing; however, mechanisms by which MSCs mitigate joint disease remain poorly understood. Galectins, a family of β-galactoside binding
Heidi L. Reesink, Ryan M. Sutton, Carolyn R. Shurer, Ryan P. Peterson, Julie S. Tan, Jin Su, Matthew J. Paszek, Alan J. Nixon   +7 more
doaj   +1 more source

Association of C-type lectin-like receptor 2 and galectin-1 with portal vein system thrombosis in HBV-related liver cirrhosis

Frontiers in Medicine, 2023
Background and aimsHepatitis B virus (HBV) infection is the most common cause of liver cirrhosis. Portal venous system thrombosis (PVST) is a major complication of liver cirrhosis.
Yiyan Zhang, Yiyan Zhang, Xintong Zhang, Xiangbo Xu, Xiangbo Xu, Xiaozhong Guo, Shixue Xu, Shixue Xu, Shaoze Ma, Shaoze Ma, Jihong Chen, Jihong Chen, Xingshun Qi   +12 more
doaj   +1 more source

Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a dismal prognosis. However, while most patients die within the first year of diagnosis, very rarely, a few patients can survive for >10 years.
Brentnall, Teresa A, Chen, Ru, Crispin, David A, Dawson, David W, de Wilde, Roeland F, Lai, Lisa A, Lay, Anna R, Maitra, Anirban, May, Damon H, McIntosh, Martin W, Ottenhof, Niki A, Pan, Sheng, Simeone, Diane M, Waghray, Meghna, Wang, Shouli, Wolfgang, Christopher L   +15 more
core   +1 more source

Galectin-1 suppresses experimental colitis in mice

Gastroenterology, 2003
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions.
Santucci L, FIORUCCI, Stefano, Rubinstein N, Mencarelli A, Palazzetti B, Federici B, Rabinovich GA, Morelli A.   +7 more
openaire   +4 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Cardiac Extracellular Vesicles (EVs) Released in the Presence or Absence of Inflammatory Cues Support Angiogenesis in Different Manners [PDF]

, 2019
Cells release extracellular vesicles (EVs) to communicate in a paracrine manner with other cells, and thereby influence processes, such as angiogenesis.
Beez, Christien Madlen, Haag, Marion, Linthout, Sophie Van, Pappritz, Kathleen, Schneider, Maria, Seifert, Martina, Sittinger, Michael   +6 more
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source