Results 121 to 130 of about 93,278,916 (238)

Reduced expression of galectin-1 and galectin-9 by leucocytes in asthma patients

, 2012
Supported in part by EU–Mexico FONCICYT-C002-2009-1 ALA/127249, SAF-2008–02635 and SAF-2011–25834 from the Spanish Ministry of Science and Innovation, INDISNET (Redes Moleculares y Celulares en Enfermedades Inflamatorias) S2011/BMD-2332, MEICA (Molecular
Fuente, Hortensia de la, Lamana Domínguez, Amalia, Sanchez-Cuellar, Silvia, Giron, Rosa, Vara, Alicia, Cruz Adalia, Aranzazu, Ancochea, Julio, Cibrian, Danay, Sanchez-Madrid, Francisco   +8 more
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Galectin-3 functions an opsonin for efferocytosis in COPD : a process mediated by phosphatidylinositol 3-kinase

, 2011
Galectin-3 functions an opsonin for efferocytosis in COPD : a process mediated by phosphatidylinositol 3 ...
M Holmes (7753346), J Bylund (13718059), S Hodge (13655791), V Mukaro (13605415), P Reynolds (9570635), G Hodge (13287702), H Jersmann (13718062)   +6 more
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A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

, 2016
Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors. Mutant studies, structural analysis, and molecular modeling revealed that
Schambye, Hans, Patrick Collins (3069087), Hans Schambye, Collins, Patrick, Alison MacKinnon, Mukhopadhyay, Balaram, Ulf J. Nilsson, Blanchard, Helen, Rajput, Vishal K, Santanu Mandal, Alison MacKinnon (3069084), Hakon Leffler (200845), Tariq Sethi (317016), Ulf J. Nilsson (831832), Balaram Mukhopadhyay, Sethi, Tariq, Vishal K. Rajput (3069081), Nilsson, Ulf J, Helen Blanchard (693882), Nilsson, Ulf J., Vishal K. Rajput, Helen Blanchard, Balaram Mukhopadhyay (2420824), Hakon Leffler, Santanu Mandal (2464369), Rajput, Vishal K., Patrick Collins, Mackinnon, Alison, Mandal, Santanu, Leffler, Hakon, Hans Schambye (3069090), Tariq Sethi, Mukhopadhyay, Balaram,, Blanchard, Helen,, Schambye, Hans,, Nilsson, Ulf J.,, Mackinnon, Alison,, Sethi, Tariq,, Rajput, Vishal K.,, Collins, Patrick,, Mandal, Santanu,, Lund University., Leffler, Hakon,   +42 more
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Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.

, 2009
Galectin-1, the prototype of a family of beta-galactoside-binding proteins, has been implicated in a wide variety of biological processes. Data presented herein show that galectin-1 stimulates monocyte migration in a dose-dependent manner but is not ...
Rohit R Ghurye (16048214), Helen Stewart (4461571), Diana J Lawrence-Watt (16048217), Reshad K J Malik (16048211)   +3 more
core   +1 more source

Galectin-3 and Inflammation

Glycobiology Insights, 2016
Galectins are a family of β-galactoside-binding proteins that share a consensus sequence in the carbohydrate recognition domain (CRD). Galectin-3 is the most widely studied family member and can be found in the cellular cytoplasm and nucleus, as well as extracellularly in various tissues.
openaire   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth

Allergy, EarlyView.
Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low, Xiaohui Man, Jocelyn Ong, Anna de Beer, Sofia Papavasileiou, Srinidhi Sudharson, Seohyun Kim, Yiping Fan, Hui Hua Liew, Alicia Tay, Shihui Foo, Shanshan W. Howland, Joakim S. Dahlin, Florent Ginhoux, Jerry Kok Yen Chan, Anand Kumar Andiappan   +15 more
wiley   +1 more source

Galectin 3 [PDF]

, 2020
openaire   +2 more sources

Role of Galectin-3 in T cell activation and apoptosis

, 2007
Galectin-3，為分子量31 kDa的蛋白質，是屬於beta-galectose-binding lectin家族的一員，能正向與負向地調節T細胞和巨噬細胞的免疫功能。Galectin-3主要分布於細胞質內，然而近期研究也在細胞核、細胞表面以及細胞外間質偵測到Galectin-3的表現，暗示此分子為多功能性蛋白質。目前有越來越多的研究證據指出Galectin-3會參與調節T細胞免疫功能和細胞凋亡。Galectin-3能正向和負向地調節T細胞反應，但是Galectin ...
劉麗君, Liu, Li-Chun
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