The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]
PLoS ONE, 2011 Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo +7 more
doaj +1 more source
Assessment of serum galectin-3 levels in acute rheumatic fever
The Turkish Journal of Pediatrics, 2022 Background. Galectin-3 is a biomarker which takes a role in both acute and chronic inflammation as well as fibrosis and oxidative stress. Increased levels of it are associated with cardiovascular diseases.
Serdar Epçaçan +3 more
doaj +1 more source
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
core +1 more source
The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis
Heliyon, 2023 Background: This study aimed to compare the salivary galectin-3 and galectin-9 levels in periodontitis, gingivitis, and periodontally healthy patients. Methods: This study included 75 non-smokers who were systemically healthy.
Zerrin Barut +6 more
doaj +1 more source
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]
, 2015 Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson +81 more
core +1 more source
Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage
Frontiers in Cellular Neuroscience, 2019 Intracerebral hemorrhage (ICH) is a devastating sub-type of stroke with no proven treatment. Given the emerging role of Galectin-1 and Galectin-3 in neuroimmune responses, the objective of the current manuscript is to elucidate hemorrhagic-injury induced
Frederick Bonsack +1 more
doaj +1 more source
Survival mechanisms in B lymphoid malignancies and associated therapies [PDF]
, 2011 PhDThe apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and
Su, Bo
core +4 more sources
The role of galectin-3 and galectin-3–binding protein in venous thrombosis [PDF]
Blood, 2015 Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
Elise P, DeRoo +8 more
openaire +2 more sources
Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer [PDF]
, 2005 Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers.
Szöke, Tamas +9 more
core +1 more source
Frontiers in Molecular Neuroscience, 2017 Galectin-3, a member of the galectin protein family, has been found to regulate cell proliferation, inhibit apoptosis and promote inflammatory responses.
Yan-Chu Chen +7 more
doaj +1 more source