Results 121 to 130 of about 36,931 (245)

N‐Glycosyl Triazoline Glycomimetics via Huisgen Cycloaddition With an Electron‐Deficient Alkene and BF3‐Catalysed Triazoline Fragmentation to Aziridines

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Glycomimetics with triazoline and aziridine groups were synthesised via diastereoselective Huisgen cycloaddition from glycosyl azides. Density functional theory was applied to define the mechanism for BF3 promoted aziridine formation. Triazoline and aziridine derivatives were synthesised by diastereo‐ and regioselective Huisgen cycloaddition of 2,3,4,6‐
Aaron McCormack, Ashis Dhara, Lamis Alaa Eldin Refat, Mikael Bols, Paul V. Murphy   +4 more
wiley   +1 more source

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, Volume 13, Issue 32, 9 June 2026.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1196-1205, June 2026.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Galectin-3-A Multifunctional Molecule and a Key Player in Health and Disease. [PDF]

Molecules
Lupu Surlea A, Negreanu-Pirjol T, Olariu L, Negreanu-Pirjol BS, Jurja S, Lepadatu AC, Basa M, Rosoiu N.   +7 more
europepmc   +1 more source

TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo, Zhidong Sun, Xiao Liu, Xianni Liu, Haiwen Chen, Menglan Zhang, Weibo Mao, Yuan Cao   +7 more
wiley   +1 more source

Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation. [PDF]

Signal Transduct Target Ther
Popatia AM, Sharanek A, Jahani-Asl A.
europepmc   +1 more source

Exosome‐mediated miR‐4660 delivery inhibits OPN promoted hepatoma cells aggression through targeting LGALS3BP

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
miR‐4660 was found to be downregulated in exosomes derived from SMMC‐OPN cells, a stable HCC cell line that overexpresses OPN. LGALS3BP has been identified as a direct target of miR‐4660, with its expression levels elevated in both SMMC‐OPN cells and their secreted exosomes.
Cuihua Liu, Riwen An, Ting Lin, Lei Qu, Xiaopeng Zheng, Jingkun Lu, Mei Hong, Pengwei Zhao, Fangxin Zhao, Xuan Zhang   +9 more
wiley   +1 more source

Galectin-3 and Coronary Artery Disease: An Inflammation-Based Approach. [PDF]

J Clin Med
Bora R, Tanrıverdi R, Fidancı ŞB, Toprak B, Gülüm C, Döven O, Tamer L.   +6 more
europepmc   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source