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The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1 [PDF]
International Journal of Molecular Sciences, 2016 This review discusses the role of galectin-1 in the tumor microenvironment. First, the structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein.
Mary Cloninger
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Galectin‐1 in regenerating motoneurons
European Journal of Neuroscience, 2004AbstractThe exogenous application of recombinant galectin‐1 has recently been shown to promote the rate of peripheral nerve regeneration. Endogenous neuronal galectin‐1 expression has recently been demonstrated to increase after axotomy. Here we demonstrate a significant increase in the endogenous neuronal expression of galectin‐1 mRNA in facial ...
J, McGraw +7 more
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Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus
British Journal of Ophthalmology, 2018AimsTo evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen cross-linking (CXL) treatment in vitro.MethodsTear fluid, cornea samples and conjunctival impression cytology specimens from control and KC patients were used to evaluate Gal-1 and Gal-3 expressions ...
Frans Eberth Costa Andrade +7 more
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Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease
Placenta, 2004While the presence and distribution of galectin-1 and galectin-3 in different normal trophoblast cell populations is known, no information is available regarding their occurrence in malignant trophoblast of gestational trophoblastic disease (GTD). Galectins-1 and -3 have, however, been implicated in malignancies of other tissues.
M, Bozić +5 more
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Understanding the biochemical activities of galectin-1 and galectin-3 in the nucleus
Glycoconjugate Journal, 2002Nuclear extracts (NE), capable of carrying out splicing of pre-mRNA, contain galectin-1 and galectin-3. NE depleted of galectins-1 and -3 concomitantly lose their splicing activity. The activity of the galectin-depleted extract can be reconstituted by the addition of either galectin-1 or galectin-3.
Ronald J, Patterson +2 more
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The Significance of Galectin-1 and Galectin-9 Expression in Endometrial Carcinoma
Gynecologic and Obstetric Investigation, 2019<b><i>Objectives:</i></b> To explore the expression of Galectin-1 and -9 and clinicopathological features in endometrial carcinoma (EC). <b><i>Methods:</i></b> Normal endometrium (NE), atypical endometrial hyperplasia (AH), and endometrial cancer were collected, and immunohistochemistry was used to detect
Xiao-Fei, Sun, Shu-Yan, Dai
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Galectin-1 and HIV-1 Infection
2010Initial binding of human immunodeficiency virus-1 (HIV-1) to its susceptible CD4(+) cells is the limiting step for the establishment of infection as the avidity of viral envelope gp120 for CD4 is not high and the number of viral envelope spikes on the surface is found to be low compared to highly infectious viruses. Several host factors, such as C-type
Christian, St-Pierre +3 more
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Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma
Human Pathology, 2001Galectins, a family of beta-galactoside-binding animal lectins, might be involved in tumor progression. In this study, the expression patterns of galectin-1 and -3 were examined immunohistochemically in intrahepatic cholangiocarcinoma (ICC), with emphasis on its development and progression as well as its histopathologic features, by use of samples of ...
T, Shimonishi +8 more
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The immunological potential of galectin-1 and -3
Autoimmunity Reviews, 2009A family of beta-galactosides-binding proteins, called galectins, have recently emerged as novel molecules with immunoregulatory functions. These proteins are expressed in both inflammatory and non-inflammatory cells including monocytes, macrophages, dendritic cells, mast cells, and B and T cells, giving a broad spectrum of involvement in the immune ...
A. Dhirapong +4 more
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Expert Review of Neurotherapeutics, 2020
Introduction: Neuroinflammation has been proposed as a common factor and one of the main inducers of neuronal degeneration. Galectins are a group of β-galactoside-binding lectins, that play an important role in the immune response, adhesion, proliferation, differentiation, migration and cell growth.
Eleazar, Ramírez Hernández +6 more
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Introduction: Neuroinflammation has been proposed as a common factor and one of the main inducers of neuronal degeneration. Galectins are a group of β-galactoside-binding lectins, that play an important role in the immune response, adhesion, proliferation, differentiation, migration and cell growth.
Eleazar, Ramírez Hernández +6 more
openaire +2 more sources