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Galectins as Cancer Biomarkers
Cancers, 2010 Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence elements of the carbohydrate recognition domain (CRD). Proteins similar to galectins can be found in very primitive animals such as sponges. Each galectin has an individual carbohydrate binding preference and can be found in cytoplasm as well as in the ...
Vitaly Balan +2 more
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Inhibition and Detection of Galectins
ChemBioChem, 2006AbstractMore and more studies report on the roles that galectins play in numerous types of cancer. These roles can be varied, as has been shown particularly for galectin‐3. These studies have created the need for inhibitors that can block unwanted effects, and the need to detect galectins in tissues, in order to better understand their role, and aid in
Roland J Pieters
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Roles of galectins in infection [PDF]
Nature Reviews Microbiology, 2009 Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous ('self') carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and ...
Gerardo R Vasta, Vasta Gerardo R
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Glycoconjugate Journal, 2002
Good evidence suggest roles of galectins in cancer, immunity and inflammation, and development, but a unifying picture of their biological function is lacking. Instead galectins appear to have a particularly diverse, bewildering but intriguing array of activities both inside and outside cells--"clear truths and mysteries are inextricably twined ...
Hakon, Leffler +4 more
openaire +2 more sources
Good evidence suggest roles of galectins in cancer, immunity and inflammation, and development, but a unifying picture of their biological function is lacking. Instead galectins appear to have a particularly diverse, bewildering but intriguing array of activities both inside and outside cells--"clear truths and mysteries are inextricably twined ...
Hakon, Leffler +4 more
openaire +2 more sources
Taloside Inhibitors of Galectin‐1 and Galectin‐3
Chemical Biology & Drug Design, 2012Galectin‐1 and galectin‐3 have roles in cancer and inflammation. Galectin‐1 has recently emerged as a significant protein produced by tumour cells to promote tumour development, angiogenesis and metastasis and consequently represents an important target to inhibit.
Collins, Patrick M +4 more
openaire +3 more sources
2006
Galectins are a family of animal lectins with affinity for beta-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively
Daniel K, Hsu +2 more
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Galectins are a family of animal lectins with affinity for beta-galactosides. By using recombinant proteins, a number of galectins have been shown to interact with cell-surface and extracellular matrix glycoconjugates through lectin-carbohydrate interactions. Through this action, they can affect a variety of cellular processes, and the most extensively
Daniel K, Hsu +2 more
openaire +2 more sources
The interrelation of galectins and autophagy
International Immunopharmacology, 2023Autophagy is a vital physiological process that maintains intracellular homeostasis by removing damaged organelles and senescent or misfolded molecules. However, excessive autophagy results in cell death and apoptosis, which will lead to a variety of diseases.
Lujuan Zheng +9 more
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Galectins and Neuroinflammation
2014Galectins, β-galactoside-binding lectins, play multiple roles in the regulation of immune and inflammatory responses. The major galectins expressed in the CNS are galectins 1, 3, 4, 8, and 9. Under normal physiological conditions, galectins maintain CNS homeostasis by participating in neuronal myelination, neuronal stem cell proliferation, and apical ...
Hung-Lin, Chen +3 more
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