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The interrelation of galectins and autophagy
International Immunopharmacology, 2023Autophagy is a vital physiological process that maintains intracellular homeostasis by removing damaged organelles and senescent or misfolded molecules. However, excessive autophagy results in cell death and apoptosis, which will lead to a variety of diseases.
Lujuan Zheng +9 more
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Galectin-8: a complex sub-family of galectins (Review)
International Journal of Molecular Medicine, 2001Galectins are animal lectins, that can specifically bind beta-galactosides. Twelve galectins have been described in vertebrates, belonging to three different groups: prototype, tandem-repeat and chimeric. These proteins seem to be involved in cellular interactions and neoplastic transformations.
N, Bidon +4 more
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Glycoconjugate Journal, 2002
Galectin-3, a 31 kDa member of the beta-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and ...
Yukinori, Takenaka +2 more
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Galectin-3, a 31 kDa member of the beta-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and ...
Yukinori, Takenaka +2 more
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The Laryngoscope, 2001
AbstractObjectives To investigate whether galectins 1, 3, and 8 are expressed in human cholesteatomas and whether any such expression does correlate with the level of apoptosis, which is, as we have previously shown, predictive of recurrence. 7Study Design The analysis of 52 cholesteatomas resected by the same surgeon by means of canal wall up and ...
Sheikholeslam-zadeh, R +10 more
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AbstractObjectives To investigate whether galectins 1, 3, and 8 are expressed in human cholesteatomas and whether any such expression does correlate with the level of apoptosis, which is, as we have previously shown, predictive of recurrence. 7Study Design The analysis of 52 cholesteatomas resected by the same surgeon by means of canal wall up and ...
Sheikholeslam-zadeh, R +10 more
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Galectins in Kidney Development
Glycoconjugate Journal, 2002Galectins are a family of proteins with overlapping but distinct carbohydrate-binding specificities. They differ in cell-type and tissue distribution, and have various functions. Extracellularly several galectins can modulate cellular adhesive interactions and signalling pathways, effects that may be important in the establishment and maintenance of ...
R Colin Hughes
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Clinica Chimica Acta, 2014
Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-
Lin, Song +5 more
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Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-
Lin, Song +5 more
openaire +2 more sources
Examination of the Role of Galectins and Galectin Inhibitors in Endothelial Cell Biology
2014The growth of new blood vessels is a key event in many (patho)physiological processes, including embryogenesis, wound healing, inflammatory diseases, and cancer. Neovascularization requires different, well-coordinated actions of endothelial cells, i.e., the cells lining the luminal side of all blood vessels.
Schulkens, I.A.E. +4 more
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Biochemical Society Symposia, 2002
The mutational analysis of the galectin family is shedding a different light of this class of molecules. On the one hand, it appears that galectin 1 and galectin 3 are not required for the survival of mice in normal animal house conditions, while on the other hand, there seems to be several subtle, but very complex, consequences of lacking galectins ...
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The mutational analysis of the galectin family is shedding a different light of this class of molecules. On the one hand, it appears that galectin 1 and galectin 3 are not required for the survival of mice in normal animal house conditions, while on the other hand, there seems to be several subtle, but very complex, consequences of lacking galectins ...
openaire +2 more sources
The Role of Galectins in Immunity and Infection
Nature Reviews Immunology, 2023Sean R Stowell, Fu-Tong Liu
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Galectins as Pivotal Components in Oncogenesis and Immune Exclusion in Human Malignancies
Frontiers in Immunology, 2023Pierre Busson
exaly