Results 111 to 120 of about 53,197 (218)

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, Volume 117, Issue 8, Page 2085-2097, August 2026.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Rare pathological types of gallbladder cancer: Cases report. [PDF]

Medicine (Baltimore)
Wang H, Wang Z, Zhao Y, Xiang Y, Li J, Tuo H.   +5 more
europepmc   +1 more source

Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice—Insights From the AROS Database

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6787-6800, August 2026.
ABSTRACT Aims To quantify real‐world diagnosis and treatment of obesity in Sweden, describe cardiometabolic comorbidity burden across obesity classes, and compare long‐term cardiovascular outcomes with the general population. Materials and Methods This population‐based cohort study used the AROS (Analysis of Real‐world data of patients with Obesity in ...
Viveca Ritsinger, Magnus Sundbom, Jonatan Dereke, Åsa Ericsson, Thomas Cars, Maria K. Svensson, Anna Norhammar   +6 more
wiley   +1 more source

ω-3PUFAs Inhibit Gallbladder Cancer Through Enhancing STK31 Methylation. [PDF]

Mol Nutr Food Res
Li SX, Zhu WY, Peng HY, Zhang B, Lin ZY, Yang SL, Zhao YY, Gao H, He S, Liu Y, Wang XD, Guo YF, Wang WJ, Hou ZL, Meng MY, Liao LW, Li L.   +16 more
europepmc   +1 more source

Survodutide for the Treatment of Obesity Disease in Japanese Participants: Rationale, Design and Baseline Characteristics of the Phase 3 SYNCHRONIZE‐JP Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6595-6606, August 2026.
ABSTRACT Aims There is an unmet need for effective pharmacotherapy for obesity disease management in Japan. Survodutide is a novel glucagon receptor/glucagon‐like peptide‐1 receptor (GLP‐1R) dual agonist with the potential to induce greater weight reductions than GLP‐1R mono‐agonists. We report the design and baseline participant characteristics of the
Koutaro Yokote, Toshimasa Yamauchi, Yasushi Fukushima, Yoji Takatsuka, Marie Kato, Shijia Yan, Takayoshi Inoue, Luiza Borowska, Martina Brueckmann, Wataru Ogawa, on behalf of the SYNCHRONIZE‐JP Trial Investigators   +10 more
wiley   +1 more source

Development and validation of a nomogram for predicting postoperative survival in gallbladder cancer. [PDF]

Transl Gastroenterol Hepatol
Qiu YY, Huang Q, Sun MQ, He XD, Han XL, Zhang N.   +5 more
europepmc   +1 more source

Patient Expectations in High‐Risk Abdominal Surgery for Cancer

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Background Despite the central role of expectations in informed consent and surgical shared decision‐making, patient expectations frequently remain unelicited or underexplored and are often assumed rather than explicitly addressed. Objective To explore how patients form expectations about high‐risk abdominal surgery for cancer and how ...
Kimberly E. Kopecky, Jacquelyn E. F. Speer, Janet Julson, Alizeh Abbas, Olivia Monton, Fabian M. Johnston, J. Nicholas Odom   +6 more
wiley   +1 more source

Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah, Werner Dammermann, Stefan Lueth   +2 more
wiley   +1 more source

Protein Expression Analysis and Functional Characterization of Sorcin in Gallbladder Cancer. [PDF]

Cells
Jain V, Saklani N, Kawatra S, Sakhuja P, Goyal S, Agarwal AK, Kumar P, Siraj F, Gautam P.   +8 more
europepmc   +1 more source

Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta‐Analysis

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to identify common life‐course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood. Methods Observational studies were identified that assessed the association of BMI trajectories with
Samira Behboudi‐Gandevani, Tommy Haugan, Nayla Cristina Do Vale Moreira, Ellen Christin Arntzen, Moira Strand Hutchinson, Melanie Nichols, Razieh Bidhendi‐Yarandi   +6 more
wiley   +1 more source