Results 71 to 80 of about 921,883 (255)
BMC Psychology, 2023 Background Online game addiction has become a prominent public concern, particularly among emerging adults, warranting in-depth investigation. Despite prior cross-sectional research indicating a negative correlation between gratitude and online gaming ...
Bin Gao +4 more
doaj +1 more source
Prestasi Belajar Siswa Ditinjau Dari Kecanduan Game Online dan Motivasi Belajar
Psychocentrum Review, 2021 The low student achievement is indicated because it is influenced by the level of game online and students learning motivation. The purposes of this study are 1) to determine the effect of online game addiction and learning motivation on learning ...
Briti Nursita +2 more
doaj +1 more source
International Journal of Progressive Education, 2021 In this study, it was examined whether empathy is related to video game addiction and whether psychological resilience and life satisfaction mediate this relationship.
Mehmet Emin Turan
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Digital game addiction and lifestyle behaviors in Turkish adolescents
Clinical and Experimental Health Sciences, 2021 Objective: Digital game addiction is a concern that threatens public health around the world, especially in adolescents. This study was conducted to determine the relationship between digital game addiction and lifestyle behaviors in adolescents. Methods:
Z. Aksoy, Saime Erol
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Hubungan antara Kecanduan Game Internet dengan Keterampilan Sosial pada Remaja di Kota Yogyakarta
Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal), 2022 Background: Most Indonesians are internet users. Adolescents, who are active internet users and use internet for playing game too often, have the risk of experiencing online gaming addiction. Internet game addict may possess poor social skills. Objective:
Devina Ngeksi Hari Laksono +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Psychiatry Investigation, 2021 Objective This study examined the mediating effect of mindfulness and consciousness among five factors on the effect of stress on Internet game addiction tendency.
Tae-Jung Choi, J. Park, D. Kim
semanticscholar +1 more source