Results 231 to 240 of about 173,531 (306)

Elements and roadmap for interactive molecular graphics and modeling "in the Holodeck". [PDF]

Protein Sci
Mulholland AJ, Abriata LA.
europepmc   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

Intraspecific Contact Among White-Tailed Deer: A Literature Review and Chronic Wasting Disease Case Study. [PDF]

Ecol Evol
Wehr NH, Bondo KJ, Rosenberry CS, Stainbrook D, Wallingford BD, Walter WD.   +5 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Toward more economical large-scale foundation models: No longer a game for the few. [PDF]

Innovation (Camb)
Wu Y, Zhang Z, Wang F, Xu Y, Huang J.
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

QSProteome: a community-driven interactive platform for large-scale exploration and evaluation of predicted protein complex structures. [PDF]

Nucleic Acids Res
Catoiu EA, Kambo D, Rodriguez B, Vear K, Wang Z, Akpata J, Shah J, Ayoub R, Hofmann M, Ananda K, Tantry A, Gupta I, Anwyl R, Faucher C, Nichols J, Ton B, Marchal LO, Palsson BO.   +17 more
europepmc   +1 more source

Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

Development and validation of an ethical monopoly board game to teach bioethics to undergraduate medical students. [PDF]

BMC Med Educ
Fatima A, Mahboob U, Khan RA, Rafique S.
europepmc   +1 more source

Every "Body" Gets a Say: An Augmented Optimization Metric to Preserve Body Pose During Avatar Adaptation in Mixed/Augmented Reality. [PDF]

IEEE Trans Vis Comput Graph
Watkins A, Ullal A, Sarkar N.
europepmc   +1 more source