Results 41 to 50 of about 174,191 (305)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Think Spatially With Game Engine [PDF]
ISPRS International Journal of Geo-Information, 2020 Spatial thinking and spatial orientation skills are involved in tasks related to the recognition of landforms, mapping, spatial interpretation, and landscape analysis, and can be developed with specific training. Game engines can facilitate the creation of 3D virtual landforms and provide powerful rendering engines for the graphical representation of ...
Carlos Carbonell-Carrera +3 more
openaire +2 more sources
User Satisfaction in Competitive Sponsored Search
, 2013 We present a model of competition between web search algorithms, and study the impact of such competition on user welfare. In our model, search providers compete for customers by strategically selecting which search results to display in response to user
Kempe, David, Lucier, Brendan
core +1 more source
TCEC14: the 14th top chess engine championship [PDF]
, 2019 TCEC14 was the 14th season of the Top Chess Engine Championship and ran from December 14th 2018 to 23rd February 2019. TCEC has become the largest Open Computer Chess Championship. It attracts the best engines in the field and provides an opportunity for
Haworth, Guy, Hernandez, Nelson
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Collaborative soft object manipulation for game engine-based virtual reality surgery simulators [PDF]
, 2011 In this paper we analyse and evaluate the capabilities of popular game engines to simulate and interact with soft objects. We discuss how these engines can be used for simulated surgical training applications, determine their shortcomings and make ...
Marks, S, Windsor, JA, Wünsche, B
core
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Game Engine Comparative Anatomy
, 2022 Video game developers use game engines as a tool to manage complex aspects of game development. While engines play a big role in the success of games, to the best of our knowledge, they are often developed in isolation, in a closed-source manner, without architectural discussions, comparison, and collaboration among projects.
Gabriel C. Ullmann +3 more
openaire +2 more sources
A Multi-agent System for Autonomous Control of Game Parameters [PDF]
, 2013 International audienceControl of game parameters to reach domain-related objectives cannot be easily handled with classic control theory approaches. Given the dynamics and complexity of modern game engines, diversity of human players and their constantly
Bernon, Carole, Pons, Luc
core +4 more sources