Results 141 to 150 of about 893,285 (266)

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Unlocking success: community engagement for enhanced HIV care outcomes. [PDF]

Res Involv Engagem
Wiehe SE, Nelson TL, Hawryluk B, Andres UM, Aalsma MC, Rosenman MB, Butler MS, Harris M, Moore K, Scott CD, Gharbi S, Parks L, Lynch D, Silverman RD, Fortenberry JD.   +14 more
europepmc   +1 more source

"Research Jam": Engaging patients and other stakeholders through human-centered design to improve translational research. [PDF]

J Clin Transl Sci, 2023
Wiehe SE, Moore CM, Lynch DO, Claxton G, Bauer NS, Sanematsu H.   +5 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Additional VR-based training improves upper extremity functions in subacute stroke patients: a single-blinded pairwise-matched trial. [PDF]

Front Neurol
Dordevic M, Wendt C, Külzow N, Kundu S, Haun C, Baier B, Gorsler A, Müller NG.   +7 more
europepmc   +1 more source

Game Algorithm of Intelligent Driving Vehicle Based on Left-Turn Scene of Crossroad Traffic Flow. [PDF]

Comput Intell Neurosci, 2022
Guo Z, Sun D, Zhou L.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Dynamic Traffic Signal Control for Isolated Intersections: Enhanced SARSA Reinforcement Learning with Expectation Prediction and Eligibility Traces. [PDF]

Sensors (Basel)
Gao Y, Sun W, Jian M, Zhang Z, Yan Z.
europepmc   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Heterogeneity, reinforcement learning, and chaos in population games. [PDF]

Proc Natl Acad Sci U S A
Bielawski J, Chotibut T, Falniowski F, Misiurewicz M, Piliouras G.   +4 more
europepmc   +1 more source