Results 1 to 10 of about 14,920 (249)

Antibody Responses to Crude Gametocyte Extract Predict Plasmodium falciparum Gametocyte Carriage in Kenya [PDF]

Frontiers in Immunology, 2021
BackgroundMalaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key to malaria elimination and/or ...
Brian R. Omondi, Brian R. Omondi, Michelle K. Muthui, William I. Muasya, Benedict Orindi, Ramadhan S. Mwakubambanya, Teun Bousema, Chris Drakeley, Kevin Marsh, Kevin Marsh, Philip Bejon, Philip Bejon, Melissa C. Kapulu, Melissa C. Kapulu   +13 more
doaj   +7 more sources

Risk factor for gametocyte carriage and gametocytemia in Plasmodium vivax and Plasmodium falciparum [PDF]

Infectious Diseases of Poverty
Background Understanding Plasmodium sexual differentiation is crucial for blocking transmission. This study identified risk factors for gametocyte carriage and gametocytemia in P. vivax and P.
Minxi Li, Yang Bian, Shishao Ruan, Zifang Wu, Di Zhang, Tongyu Ma, Yaming Wu, Xiao Liu, Duo Wang, Jia Lin, Danni Pan, Wenyan Cui, Lin Wang, Haichao Wei, Xuexing Zhang, Qinghui Wang, Weilin Zeng, Zhaoqing Yang, Yaming Cao, Liwang Cui, Daniel M. Parker, Yan Zhao   +21 more
doaj   +2 more sources

Risk factors for Plasmodium falciparum gametocyte positivity in a longitudinal cohort. [PDF]

PLoS ONE, 2015
Malaria transmission intensity is highly heterogeneous even at a very small scale. Implementing targeted intervention in malaria transmission hotspots offers the potential to reduce the burden of disease both locally and in adjacent areas.
Laura Grange, Cheikh Loucoubar, Olivier Telle, Adama Tall, Joseph Faye, Cheikh Sokhna, Jean-François Trape, Anavaj Sakuntabhai, Jean-François Bureau, Richard Paul   +9 more
doaj   +3 more sources

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study [PDF]

Malaria Journal, 2017
Background Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle.
Yaw Adomako-Ankomah, Matthew S. Chenoweth, Aaron M. Tocker, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Abdoul S. Keita, Jennifer M. Anderson, Rick M. Fairhurst, Mahamadou Diakite, Kazutoyo Miura, Carole A. Long   +11 more
doaj   +2 more sources

Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. [PDF]

PLoS ONE, 2009
BACKGROUND:Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities.
André Lin Ouédraogo, Teun Bousema, Petra Schneider, Sake J de Vlas, Edith Ilboudo-Sanogo, Nadine Cuzin-Ouattara, Issa Nébié, Will Roeffen, Jan Peter Verhave, Adrian J F Luty, Robert Sauerwein   +10 more
doaj   +3 more sources

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea. [PDF]

PLoS ONE, 2015
A better understanding of human-to-mosquito transmission is crucial to control malaria. In order to assess factors associated with gametocyte carriage, 2083 samples were collected in a cross-sectional survey in Papua New Guinea.
Cristian Koepfli, Leanne J Robinson, Patricia Rarau, Mary Salib, Naomi Sambale, Rahel Wampfler, Inoni Betuela, Wang Nuitragool, Alyssa E Barry, Peter Siba, Ingrid Felger, Ivo Mueller   +11 more
doaj   +8 more sources

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes. [PDF]

PLoS Pathogens
Reducing malaria transmission has been a major pillar of control programmes and is considered crucial for achieving malaria elimination. Gametocytes, the transmissible forms of the P.
Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E Otoboh, Jahiro Gomez, Lorena Coronado, Karl B Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti   +13 more
doaj   +2 more sources

Prevalence of asymptomatic P. falciparum gametocyte carriage among school children in Mbita, Western Kenya and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research, 2021
Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria.
Abdoulie O. Touray, Victor A. Mobegi, Fred Wamunyokoli, Hellen Butungi, Jeremy K. Herren   +4 more
doaj   +1 more source

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Frontiers in Immunology, 2022
Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes.
Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K.A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Teun Bousema, Will J.R. Stone   +16 more
doaj   +1 more source

Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density

Malaria Journal, 2021
Background Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants.
Paul Sondo, Biebo Bihoun, Marc Christian Tahita, Karim Derra, Toussaint Rouamba, Seydou Nakanabo Diallo, Adama Kazienga, Hamidou Ilboudo, Innocent Valea, Zekiba Tarnagda, Hermann Sorgho, Thierry Lefèvre, Halidou Tinto   +12 more
doaj   +1 more source