Results 1 to 10 of about 7,720 (145)

Risk factor for gametocyte carriage and gametocytemia in Plasmodium vivax and Plasmodium falciparum [PDF]

Infectious Diseases of Poverty
Background Understanding Plasmodium sexual differentiation is crucial for blocking transmission. This study identified risk factors for gametocyte carriage and gametocytemia in P. vivax and P.
Minxi Li, Yang Bian, Shishao Ruan, Zifang Wu, Di Zhang, Tongyu Ma, Yaming Wu, Xiao Liu, Duo Wang, Jia Lin, Danni Pan, Wenyan Cui, Lin Wang, Haichao Wei, Xuexing Zhang, Qinghui Wang, Weilin Zeng, Zhaoqing Yang, Yaming Cao, Liwang Cui, Daniel M. Parker, Yan Zhao   +21 more
doaj   +2 more sources

Associations between Season and Gametocyte Dynamics in Chronic Plasmodium falciparum Infections.

PLoS ONE, 2016
IntroductionIn a markedly seasonal malaria setting, the transition from the transmission-free dry season to the transmission season depends on the resurgence of the mosquito population following the start of annual rains.
Amal A H Gadalla, Petra Schneider, Thomas S Churcher, Elkhansaa Nassir, Abdel-Muhsin A Abdel-Muhsin, Lisa C Ranford-Cartwright, Sarah E Reece, Hamza A Babiker   +7 more
doaj   +2 more sources

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study [PDF]

Malaria Journal, 2017
Background Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle.
Yaw Adomako-Ankomah, Matthew S. Chenoweth, Aaron M. Tocker, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Abdoul S. Keita, Jennifer M. Anderson, Rick M. Fairhurst, Mahamadou Diakite, Kazutoyo Miura, Carole A. Long   +11 more
doaj   +2 more sources

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes. [PDF]

PLoS Pathogens
Reducing malaria transmission has been a major pillar of control programmes and is considered crucial for achieving malaria elimination. Gametocytes, the transmissible forms of the P.
Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E Otoboh, Jahiro Gomez, Lorena Coronado, Karl B Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti   +13 more
doaj   +2 more sources

An improved multiplex RT-quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections. [PDF]

J Antimicrob Chemother
Ciardo M, Henry NB, Soulama I, Sermé SS, Rotili D, Mai A, Lombardo F, Alano P, Siciliano G.   +8 more
europepmc   +3 more sources

Prevalence of asymptomatic P. falciparum gametocyte carriage among school children in Mbita, Western Kenya and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research, 2021
Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria.
Abdoulie O. Touray, Victor A. Mobegi, Fred Wamunyokoli, Hellen Butungi, Jeremy K. Herren   +4 more
doaj   +1 more source

Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density

Malaria Journal, 2021
Background Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants.
Paul Sondo, Biebo Bihoun, Marc Christian Tahita, Karim Derra, Toussaint Rouamba, Seydou Nakanabo Diallo, Adama Kazienga, Hamidou Ilboudo, Innocent Valea, Zekiba Tarnagda, Hermann Sorgho, Thierry Lefèvre, Halidou Tinto   +12 more
doaj   +1 more source

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Frontiers in Immunology, 2022
Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes.
Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K.A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Teun Bousema, Will J.R. Stone   +16 more
doaj   +1 more source

The activity of methylene blue against asexual and sexual stages of Plasmodium vivax

Frontiers in Cellular and Infection Microbiology, 2023
Methylene blue (MB) is an alternative for combating drug-resistant malaria parasites. Its transmission-blocking potential has been demonstrated in vivo in murine models, in vitro, and in clinical trials.
Camila Fabbri, Camila Fabbri, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Alexandre Oliveira Trindade, Luis Carlos Salazar-Alvarez, Juliana Costa Ferreira Neves, Juliana Costa Ferreira Neves, Ivanildes dos Santos Bastos, Ivanildes dos Santos Bastos, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Wuelton Marcelo Monteiro, Wuelton Marcelo Monteiro, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes   +27 more
doaj   +1 more source

Erythrocyte tropism of malarial parasites: The reticulocyte appeal

Frontiers in Microbiology, 2022
Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood
Yew Wai Leong, Bruce Russell, Benoit Malleret, Benoit Malleret, Laurent Rénia, Laurent Rénia, Laurent Rénia   +6 more
doaj   +1 more source