Results 31 to 40 of about 9,642 (218)

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions

Frontiers in Immunology, 2022
Malaria transmission depends on the presence of mature Plasmodium transmission stages (gametocytes) that may render blood-feeding Anopheles mosquitos infectious.
Jordache Ramjith, Jordache Ramjith, Manon Alkema, John Bradley, Alassane Dicko, Chris Drakeley, Will Stone, Teun Bousema   +7 more
doaj   +1 more source

HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya

Frontiers in Cellular and Infection Microbiology, 2021
As morbidity and mortality due to malaria continue to decline, the identification of individuals with a high likelihood of transmitting malaria is needed to further reduce the prevalence of malaria.
Deborah M. Stiffler, Janet Oyieko, Carolyne M. Kifude, David M. Rockabrand, Shirley Luckhart, V. Ann Stewart   +5 more
doaj   +1 more source

Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes. [PDF]

, 2010
BACKGROUND: Antimalarial interventions designed to impact on the transmissible sexual stages of Plasmodium falciparum are evaluated by measurement of peripheral gametocyte carriage in vivo and infectivity to mosquitoes.
Sutherland, Colin J, Drakeley, Chris J, Drakeley Chris J., Samana Schwank, Schwank, Samana, Chris J. Drakeley, Colin J Sutherland, Sutherland Colin J., Schwank Samana, Colin J. Sutherland, Chris J Drakeley   +10 more
core   +2 more sources

Transmission immunity in malaria: reflections on the underlying immune mechanisms during natural infections and following artificial immunization

Memorias do Instituto Oswaldo Cruz, 1992
Malaria transmission-blocking immunity has been studied in natural malaria infections in man, during infections in animals and following artificial immunization of animals with sexual stage malaria parasites.
Richard Carter, Kamini Mendis
doaj   +1 more source

Revisiting gametocyte biology in malaria parasites [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACT Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed ...
Ngotho, Priscilla, Blancke Soares, Alexandra, Hentzschel, Franziska, Achcar, Fiona, Bertuccini, Lucia, Marti, Matthias   +5 more
openaire   +2 more sources

Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionUnderstanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates ...
Katherine O’Flaherty, Jo-Anne Chan, Jo-Anne Chan, Jo-Anne Chan, Julia C. Cutts, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Arjen M. Dondorp, Nicholas P. Day, Nicholas P. Day, Mehul Dhorda, Mehul Dhorda, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, Mayfong Mayxay, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Caterina Fanello, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Michael Theisen, Francois Nosten, Francois Nosten, Francois Nosten, James G. Beeson, James G. Beeson, James G. Beeson, James G. Beeson, Julie A. Simpson, Nicholas J. White, Nicholas J. White, Freya J. I. Fowkes, Freya J. I. Fowkes, Freya J. I. Fowkes   +50 more
doaj   +1 more source

Gametocytes: insights gained during a decade of molecular monitoring [PDF]

, 2008
In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new ...
Babiker, Hamza A., Reece, Sarah E., Schneider, Petra   +2 more
core   +1 more source

Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum [PDF]

, 2006
OBJECTIVES: Treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the prevalence and density of gametocytes. We did a randomized trial to determine the effect of treatment of asymptomatic infections
Dunyo, SK, Milligan, P, Edwards, T, Milligan, Paul, Edwards, Tansy, Dunyo, Samuel, Pinder, Margaret, Sutherland, Colin, Targett, Geoffrey   +8 more
core   +1 more source

Sex ratios in the rodent malaria parasite, Plasmodium chabaudi [PDF]

, 2003
The sex ratios of malaria and related Apicomplexan parasites play a major role in transmission success. Here, we address 2 fundamental issues in the sex ratios of the rodent malaria parasite, Plasmodium chabaudi.
West, SA, West, S A, Read, A F, REECE, S. E., West, S. A., Read, A. F., Duncan, A B, West, Stuart A, Reece, S E, Duncan, A., Reece, SE, Duncan, AB, Read, AF, Duncan, Alison B, Read, Andrew F   +14 more
core   +1 more source

Identification and analysis of Eimeria nieschulzi gametocyte genes reveal splicing events of gam genes and conserved motifs in the wall-forming proteins within the genus Eimeria (Coccidia, Apicomplexa)

Parasite, 2017
The genus Eimeria (Apicomplexa, Coccidia) provides a wide range of different species with different hosts to study common and variable features within the genus and its species.
Wiedmer Stefanie, Erdbeer Alexander, Volke Beate, Randel Stephanie, Kapplusch Franz, Hanig Sacha, Kurth Michael   +6 more
doaj   +1 more source