Results 41 to 50 of about 9,642 (218)

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

Malaria Journal, 2017
Background Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes ...
Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein   +8 more
doaj   +1 more source

A randomized open-label trial of artesunate- sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. [PDF]

, 2007
BACKGROUND: In areas of seasonal malaria transmission, treatment of asymptomatic carriers of malaria parasites, whose parasitaemia persists at low densities throughout the dry season, could be a useful strategy for malaria control.
El-Sayed, Badria, Ageep, Tellal, Salah-Eldin El-Zaki, Ahmed Babiker, Fathi Mansour, Nahla Gadalla, Tellal Ageep, Paul Milligan, El-Sayed Badria, Babiker Hamza, Baraka Omer, Babiker, Hamza, Milligan Paul, Milligan, Paul, El-Zaki Salah-Eldin, Omer Baraka, Gadalla Nahla, Gadalla, Nahla, Baraka, Omer, Babiker Ahmed, Ageep Tellal, Badria El-Sayed, Babiker, Ahmed, Mansour, Fathi, Mansour Fathi, Hamza Babiker, El-Zaki, Salah-Eldin   +26 more
core   +1 more source

Ultrastructure and function of mitochondria in gametocytic stage of Plasmodium falciparum

Parasite, 2000
Morphological properties of the mitochondrial organelles in the asexual and sexual gametocytic stages of Plasmodium falciparum have been analyzed and found to be markedly different.
Krungkrai J., Prapunwattana P., Krungkrai S.R.   +2 more
doaj   +1 more source

Plasmodium falciparumgametocytes: with a view to a kill [PDF]

Parasitology, 2013
SUMMARYDrugs that kill or inhibit the sexual stages ofPlasmodiumin order to prevent transmission are important components of malaria control programmes. Reducing gametocyte carriage is central to the control ofPlasmodium falciparumtransmission as infection can result in extended periods of gametocytaemia. Unfortunately the number of drugs with activity
Butterworth, Alice S, Skinner-Adams, Tina S, Gardiner, Don L, Trenholme, Katharine R   +3 more
openaire   +5 more sources

The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso. [PDF]

, 2010
BACKGROUND: Malaria transmission depends on the presence of gametocytes in the peripheral blood. In this study, the age-dependency of gametocytaemia was examined by microscopy and molecular tools.
Sake J de Vlas, Bousema, Teun, Bousema, T. (Teun), Ouedraogo, A.L., Luty, A.J.F., Sauerwein, R.W., Vlas, S.J. (Sake) de, Ouédraogo, André Lin, Nadine Cuzin-Ouattara, Drakeley, Chris, Cuzin-Ouattara, Nadine, Luty, Adrian JF, Teun Bousema, Chris Drakeley, Verhave, JP, Luty, AJF, de Vlas, Sake J, André Ouédraogo, Robert Sauerwein, Drakeley, C, Verhave, J.P. (Jan Peter), Verhave, Jan-Peter, de Vlas, Sake, Bousema, T., Ouédraogo, A.L. (André Lin), Cuzin-Ouattara, N. (Nadine), Luty, A.J.F. (Adrian), Bousema, T, Cuzin-Ouattara, N., Sauerwein, R, Adrian JF Luty, Jan-Peter Verhave, Cuzin-Ouattara, N, Verhave, J.P., Vlas, S.J. de, Drakeley, C., André Lin Ouédraogo, Drakeley, C. (Chris), Sauerwein, R.W. (Robert), Sauerwein, Robert, Ouedraogo, AL   +40 more
core   +2 more sources

The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion. [PDF]

, 2006
Much of the epidemiology of Plasmodium falciparum in Sub-Saharan Africa focuses on the prevalence patterns of asexual parasites in people of different ages, whereas the gametocytes that propagate the disease are often neglected.
Sauerwein, Robert W, Drakeley, Chris, Drakeley, C., Sutherland, C., Bousema, J Teun, Targett, Geoffrey AT, Bousema, J.T., Sauerwein, R.W., Sutherland, Colin, Targett, G.A.T.   +9 more
core   +1 more source

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria

African Journal of Laboratory Medicine, 2018
Background: Most malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite.
Dinkorma T. Ouologuem, Cheick O. Kone, Bakary Fofana, Bakary Sidibe, Amadou H. Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara, Abdoulaye Toure, Adama Dao, Ogobara K. Doumbo, Abdoulaye A. Djimde   +13 more
doaj   +1 more source

Comparison of detection methods to estimate asexual Plasmodium falciparum parasite prevalence and gametocyte carriage in a community survey in Tanzania [PDF]

, 2014
The use of molecular techniques to detect malaria parasites has been advocated to improve the accuracy of parasite prevalence estimates, especially in moderate to low endemic settings. Molecular work is time-consuming and costly, thus the effective gains
Kabanywanyi, Abdu-Noor M., Mwingira, Felista, Felger, Ingrid, Genton, Blaise   +3 more
core   +1 more source

Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito bitingResearch in context

EBioMedicine
Summary: Background: Plasmodium blood-stage parasites balance asexual multiplication with gametocyte development. Few studies link these dynamics with parasite genetic markers in vivo; even fewer in longitudinally monitored infections.
Sara Lynn Blanken, Aissata Barry, Kjerstin Lanke, Moussa Guelbeogo, Alphonse Ouedraogo, Issiaka Soulama, Sam Aboubacar Coulibaly, Karina Teelen, Wouter Graumans, Elin Dumont, Will Stone, Jordache Ramjith, Matthias Marti, Carolina M. Andrade, Chris Drakeley, Katharine Collins, Alfred Tiono, Teun Bousema   +17 more
doaj   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source