Results 51 to 60 of about 9,642 (218)

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Drakeley, Chris J, Bousema, Teun, Sutherland, CJ, Lucy C Okell, Bousema, T, Ghani, Azra C, Sutherland Colin J, Drakeley Chris J, Drakeley, CJ, Colin J Sutherland, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Sutherland, Colin J, Ghani Azra C, Ghani, AC, Teun Bousema, Okell, LC, Chris J Drakeley   +19 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Gametocyte carriage in Plasmodium falciparum-infected travellers [PDF]

Malaria Journal, 2013
Abstract Background Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Roberts, CH, Armstrong, M, Zatyka, E, Boadi, S, Warren, S, Chiodini, PL, Sutherland, CJ, Doherty, T   +7 more
openaire   +5 more sources

Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions? [PDF]

, 2012
A recent meta-analysis of mosquito feeding assays to determine the Plasmodium falciparum transmission potential of naturally infected gametocyte carriers highlighted considerable variation in transmission efficiency between assay methodologies and ...
Bousema, T., Dinglasan, R. R., Bousema, Teun, Churcher, Thomas S, Churcher, T.S., Morlais, I., Dinglasan, Rhoel, Dinglasan, Rhoel R, Morlais, Isabelle, Dinglasan, R.R., Churcher, Thomas, Churcher, T. S.   +11 more
core   +1 more source

Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.

PLoS ONE, 2023
Antimalarial drugs that can block the transmission of Plasmodium gametocytes to mosquito vectors would be highly beneficial for malaria elimination efforts.
Noëlie B Henry, Issiaka Soulama, Samuel S Sermé, Judith M Bolscher, Tonnie T G Huijs, Aboubacar S Coulibaly, Salif Sombié, Nicolas Ouédraogo, Amidou Diarra, Soumanaba Zongo, Wamdaogo M Guelbéogo, Issa Nébié, Sodiomon B Sirima, Alfred B Tiono, Alano Pietro, Katharine A Collins, Koen J Dechering, Teun Bousema   +17 more
doaj   +1 more source

Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes

Frontiers in Cellular and Infection Microbiology, 2022
Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized.
Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V. Ann Stewart   +10 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Unraveling Occurrence Patterns and Diversity of Avian Malaria Parasites in Iberian Obligate and Facultative Scavenger Birds

Integrative Zoology, EarlyView.
Low overall haemosporidian occurrence (3.4%; 13/383). Unexpected high lineage diversity (10 new host–parasite interactions). Novel Leucocytozoon lineage (GYPBAR01) in all European vultures except the griffon vulture. Plasmodium relictum (lineage SGS1) in adult red kites.
Pilar Oliva‐Vidal, Jaime Muriel, Alfonso Marzal, Grethell Mabel López del Aguila, José María Martínez, Antoni Margalida   +5 more
wiley   +1 more source

Plasmodium falciparum Spatial Analysis, Western Kenya Highlands

Emerging Infectious Diseases, 2005
We carried out a population-based study to determine the unbiased, age-specific Plasmodium falciparum prevalence, asexual and sexual parasite density, and spatial distribution to establish rates of infection at a site in western Kenya.
Otsyula G. Munyekenye, Andrew Githeko, Guofa Zhou, Emmanuel Mushinzimana, Noboru Minakawa, Guiyun Yan   +5 more
doaj   +1 more source

Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development

Scientific Reports, 2021
Subclinical infections that serve as reservoir populations to drive transmission remain a hurdle to malaria control. Data on infection dynamics in a geographical area is required to strategically design and implement malaria interventions.
Ruth Ayanful-Torgby, Esther Sarpong, Hamza B. Abagna, Dickson Donu, Evans Obboh, Benedicta A. Mensah, Joshua Adjah, Kim C. Williamson, Linda E. Amoah   +8 more
doaj   +1 more source