Results 51 to 60 of about 13,563 (220)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria

African Journal of Laboratory Medicine, 2018
Background: Most malaria-endemic countries use artemisinin-based combination therapy (ACT) as their first-line treatment. ACTs are known to be highly effective on asexual stages of the malaria parasite.
Dinkorma T. Ouologuem, Cheick O. Kone, Bakary Fofana, Bakary Sidibe, Amadou H. Togo, Demba Dembele, Sekou Toure, Sekou Koumare, Ousmane Toure, Issaka Sagara, Abdoulaye Toure, Adama Dao, Ogobara K. Doumbo, Abdoulaye A. Djimde   +13 more
doaj   +1 more source

Malaria vaccines 1985-2005: a full circle?

, 2005
Few who were actively engaged in malaria vaccine research 20 years ago (including myself) would have imagined that, in 2005, there would still be a prediction of a 10-20-year horizon before vaccines become part of malaria-control strategies.
Targett, Geoffrey A
core   +1 more source

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

Malaria Journal, 2010
Background There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation ...
Sawa Patrick, Omar Sabah, Griffin Jamie T, Shekalaghe Seif, Okell Lucy, Bousema Teun, Sutherland Colin, Sauerwein Robert, Ghani Azra C, Drakeley Chris   +9 more
doaj   +1 more source

Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). [PDF]

, 2007
Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on ...
Alexander, Neal, Boulanger, Denis, Cissé, Badara, Greenwood, Brian M, Lines, Jo, Ntab, Balthazar, Simondon, François, Simondon, Kirsten B, Sokhna, Cheikh, Targett, Geoffrey, Trape, Jean-François   +10 more
core   +2 more sources

Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case study [PDF]

, 2015
BACKGROUND: Quantitative molecular methods (QMMs) such as quantitative real-time polymerase chain reaction (q-PCR), reverse-transcriptase PCR (qRT-PCR) and quantitative nucleic acid sequence-based amplification (QT-NASBA) are increasingly used to ...
A Gelman, André Lin Ouédraogo, B Hoadley, C Eisenhart, C Fraser, C Osborne, CE McCulloch, Cornelus Hermsen, D Lunn, DJ Lunn, DJ Spiegelhalter, DL Massart, EC Fieller, F Ferre, FA Graybill, G Marsaglia, GK Shulka, HG Niesters, HS Mubarak El, J Jiang, J Wain, JF Cohen, JH McCulloch, JM Ruijter, JN Miller, JO Beer De, JS Murray, JS Yuan, K Danzer, K Khairnar, KK Lai, LC Okell, LJ Naszódi, M Plummer, M Sivaganesan, M Woodhead, Martin Walker, María-Gloria Basáñez, NM Ferguson, P Schneider, P Schneider, P Vankeerberghen, PF Mens, R Wampfler, S Nadarajah, SA Bustin, SA Bustin, SA Fiscus, T Nolan, T Ponnudurai, TD Schmittgen, Teun Bousema, Thomas S Churcher, TS Churcher, World Health Organization, Y Karlen, YW Tang   +56 more
core   +4 more sources

Gametocyte carriage in Plasmodium falciparum-infected travellers [PDF]

Malaria Journal, 2013
Abstract Background Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Roberts, CH, Armstrong, M, Zatyka, E, Boadi, S, Warren, S, Chiodini, PL, Sutherland, CJ, Doherty, T   +7 more
openaire   +6 more sources

Plasmodium falciparum gametocyte production correlates with genetic markers of parasite replication but is not influenced by experimental exposure to mosquito bitingResearch in context

EBioMedicine
Summary: Background: Plasmodium blood-stage parasites balance asexual multiplication with gametocyte development. Few studies link these dynamics with parasite genetic markers in vivo; even fewer in longitudinally monitored infections.
Sara Lynn Blanken, Aissata Barry, Kjerstin Lanke, Moussa Guelbeogo, Alphonse Ouedraogo, Issiaka Soulama, Sam Aboubacar Coulibaly, Karina Teelen, Wouter Graumans, Elin Dumont, Will Stone, Jordache Ramjith, Matthias Marti, Carolina M. Andrade, Chris Drakeley, Katharine Collins, Alfred Tiono, Teun Bousema   +17 more
doaj   +1 more source

DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]

, 2014
BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M, Gill, Sarjeet S, Le Roch, Karine G, Lonardi, Stefano, Polishko, Anton, Ponts, Nadia, Prudhomme, Jacques   +6 more
core   +3 more sources

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, EarlyView.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source