Results 71 to 80 of about 9,642 (218)

The WD40-Protein PfWLP1 Ensures Stability of the PfCCp-Based Adhesion Protein Complex in Plasmodium falciparum Gametocytes

Frontiers in Cellular and Infection Microbiology, 2022
Members of the WD40-repeat protein family can be found in all eukaryotic proteomes where they usually serve as interaction platforms for the assembly of large protein complexes and are therefore essential for the integrity of these complexes.
Lena Roling, Ansgar Flammersfeld, Gabriele Pradel, Sandra Bennink   +3 more
doaj   +1 more source

Plasmodium Actin‐Like Proteins 3 and 5a Are Required for Subsequent Steps of Mosquito Infection

Molecular Microbiology, EarlyView.
Actin‐like proteins (Alps) are highly conserved, apicomplexan‐specific members of the actin superfamily. Using reverse genetics, we have identified that Alp3 and Alp5a are required at separate steps of transmission of the malaria parasite to its mosquito host.
Caroline Busse, Yukino Kobayashi, Andrea Diers, Annika M. Binder, Friedrich Frischknecht, Ross G. Douglas   +5 more
wiley   +1 more source

Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection [PDF]

, 2015
During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology including cerebral ...
Joice, Regina, Barteneva, Natasha S, Seydel, Karl B., Narasimhan, Vagheesh, Ma, Siyuan, Taylor, Terrie E., Pelle, Karell G, Milner, Danny A, Seydel, Karl B, Pelle, Karell G., Ketman, Ken, Brancucci, Nicolas Mb, Voss, Till S, Milner, Danny A., Pelle, Karell, Buchholz, Kathrin, Voss, Till S., Brancucci, Nicolas, Milner, Danny, Taylor, Terrie E, Huttenhower, Curtis, Marti, Matthias, Oh, Keunyoung, Barteneva, Natasha S.   +23 more
core   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Replication Data for: Antibody responses to crude gametocyte extract predicts P. falciparum gametocyte carriage in Kenya

, 2020
This is a replication dataset for the submitted manuscript titled "Antibody responses to crude gametocyte extract predicts P. falciparum gametocyte carriage in Kenya" The dataset constitutes data from two independent cross sectional studies of ...
Kapulu, Melissa C., Bousema, Teun, Orindi, Benedict, Muthui, Michelle K., Drakeley, Chris, Bejon, Philip, Muasya, William I., Marsh, Kevin, Omondi, Brian R., Mwakubambanya, Ramadhan S.   +9 more
core   +3 more sources

A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

, 2014
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which ...
Simon Brown (19585474), Paul J McMillan (9093971), Kiaran Kirk (8049), Phuong T Tran (13843015), Kai Matuschewski (118), Matthew W A Dixon (20235858), Todd Mitchell (19585504), Alexander Maier (3514112)   +7 more
core   +1 more source

Predictive Modelling of Climate‐Driven Malaria Transmission for Optimal Control Using a Coupled SEIR–SEI and GIS Framework

Public Health Challenges, Volume 5, Issue 3, September 2026.
A climate‐sensitive SEIR–SEI model coupled with GIS mapping across Zimbabwe's Mberengwa District projected a 4‐fold rise in malaria transmission under mid‐century warming. However, it showed that indoor residual spraying at 80% coverage can still achieve elimination, prioritising five high‐risk catchments for climate‐resilient intervention.
Tafadzwa Chivasa, Mlamuli Dhlamini, Auther Maviza, Wilfred Njabulo Nunu   +3 more
wiley   +1 more source

Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes [PDF]

Frontiers in Microbiology, 2019
Plasmodium falciparum sexual parasites, called gametocytes, are the only parasite stages responsible for transmission from humans to Anopheles mosquitoes. During their maturation, P. falciparum gametocytes remodel the structural and mechanical properties of the membrane of their erythrocyte host.
Gaëlle Neveu, Gaëlle Neveu, Catherine Lavazec, Catherine Lavazec   +3 more
openaire   +4 more sources

Host age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study

Malaria Journal, 2017
Background Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle.
Yaw Adomako-Ankomah, Matthew S. Chenoweth, Aaron M. Tocker, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Abdoul S. Keita, Jennifer M. Anderson, Rick M. Fairhurst, Mahamadou Diakite, Kazutoyo Miura, Carole A. Long   +11 more
doaj   +1 more source

A multiplex assay to detect mosquito species, bloodmeal host source and Plasmodium in malaria vectors using Nanopore amplicon sequencing

Medical and Veterinary Entomology, Volume 40, Issue 3, Page 465-477, September 2026.
Insectary‐reared mosquitoes were simultaneously assessed for species identification, bloodmeal source analysis and Plasmodium detection, using a single multiplexed sequencing run on the MinION sequencing platform. The method was applied to 150 insectary‐reared mosquitoes, representing nine species blood‐fed with five vertebrate hosts and 40 samples for
E. Abby Rogers, Dieunel Derilus, Christopher Sandi, Lisa Reimer, Audrey Lenhart, Lucy Mackenzie Impoinvil   +5 more
wiley   +1 more source