Results 61 to 70 of about 13,563 (220)

Gametocytes infectiousness to mosquitoes: variable selection using random forests, and zero inflated models [PDF]

, 2010
Malaria control strategies aiming at reducing disease transmission intensity may impact both oocyst intensity and infection prevalence in the mosquito vector.
Genuer, Robin, Morlais, Isabelle, Toussile, Wilson   +2 more
core   +3 more sources

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum. [PDF]

, 2015
BackgroundA vaccine that interrupts malaria transmission (VIMT) would be a valuable tool for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and mosquito stage antigens of the malaria parasite that induce immune ...
Abebe, Yonas, Billingsley, Peter F, Eappen, Abraham G, Hoffman, Stephen L, Li, Minglin, Li, Tao, Padilla, Debbie, Richman, Adam M, Rodriguez-Barraquer, Isabel, Sim, B Kim Lee   +9 more
core   +1 more source

Unraveling Occurrence Patterns and Diversity of Avian Malaria Parasites in Iberian Obligate and Facultative Scavenger Birds

Integrative Zoology, EarlyView.
Low overall haemosporidian occurrence (3.4%; 13/383). Unexpected high lineage diversity (10 new host–parasite interactions). Novel Leucocytozoon lineage (GYPBAR01) in all European vultures except the griffon vulture. Plasmodium relictum (lineage SGS1) in adult red kites.
Pilar Oliva‐Vidal, Jaime Muriel, Alfonso Marzal, Grethell Mabel López del Aguila, José María Martínez, Antoni Margalida   +5 more
wiley   +1 more source

Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.

PLoS ONE, 2023
Antimalarial drugs that can block the transmission of Plasmodium gametocytes to mosquito vectors would be highly beneficial for malaria elimination efforts.
Noëlie B Henry, Issiaka Soulama, Samuel S Sermé, Judith M Bolscher, Tonnie T G Huijs, Aboubacar S Coulibaly, Salif Sombié, Nicolas Ouédraogo, Amidou Diarra, Soumanaba Zongo, Wamdaogo M Guelbéogo, Issa Nébié, Sodiomon B Sirima, Alfred B Tiono, Alano Pietro, Katharine A Collins, Koen J Dechering, Teun Bousema   +17 more
doaj   +1 more source

Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes

Frontiers in Cellular and Infection Microbiology, 2022
Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized.
Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V. Ann Stewart   +10 more
doaj   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]

, 2020
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Abel, Steven, Batugedara, Gayani, Bottrill, Andrew R., Boucher, Matthew, Brady, Declan, Daniel, Emilie, Freville, Aline, Gupta, Dinesh, Holder, Anthony A., Hollin, Thomas, Le Roch, Karine G., Lu, Xueqing Maggie, Pandey, Rajan, Rea, Edward, Stanway, Rebecca R., Tewari, Rita, Wall, Richard J., Wheatley, Sally, Zeeshan, Mohammad   +18 more
core   +3 more sources

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Antibodies to PfsEGXP, an Early Gametocyte-Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density in Humans [PDF]

The Journal of Infectious Diseases, 2018
Antigametocyte-specific immune responses may regulate Plasmodium falciparum gametocyte density, providing the rationale for pursuing transmission-blocking vaccines (TBVs) that target gametocytes in the human host.To identify novel antigametocyte TBV antigens, we interrogated the gametocyte proteome with our whole proteome differential screening method ...
Christian P Nixon, Christina E Nixon, Ian C Michelow, Rayna A Silva-Viera, Bonnie Colantuono, Aisha S Obeidallah, Ambrish Jha, Dominique Dockery, Dipak Raj, Sangshin Park, Patrick E Duffy, Jonathan D Kurtis   +11 more
openaire   +2 more sources