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Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes [PDF]

Frontiers in Microbiology, 2019
Plasmodium falciparum sexual parasites, called gametocytes, are the only parasite stages responsible for transmission from humans to Anopheles mosquitoes. During their maturation, P. falciparum gametocytes remodel the structural and mechanical properties
Gaëlle Neveu, Catherine Lavazec
exaly   +6 more sources

Activity of Clinically Relevant Antimalarial Drugs on Plasmodium falciparum Mature Gametocytes in an ATP Bioluminescence “Transmission Blocking” Assay [PDF]

PLoS ONE, 2012
BACKGROUND: Current anti-malarial drugs have been selected on the basis of their activity against the symptom-causing asexual blood stage of the parasite.
Didier Leroy, Maria Jesus Almela, Virginia Franco   +2 more
exaly   +2 more sources

PfAP2-G2 Is Associated to Production and Maturation of Gametocytes in Plasmodium falciparum via Regulating the Expression of PfMDV-1

Frontiers in Microbiology, 2021
Gametocyte is the sole form of the Plasmodium falciparum which is transmissible to the mosquito vector. Here, we report that an Apicomplexan Apetala2 (ApiAP2) family transcription factor, PfAP2-G2 (Pf3D7_1408200), plays a role in the development of ...
Liwang Cui, Yuhao Wen
exaly   +3 more sources

Plasmodium vivax Gametocytes Adherence to Bone Marrow Endothelial Cells

Frontiers in Cellular and Infection Microbiology, 2021
In a Plasmodium vivax infection, it was shown a proportionally increased on gametocyte distribution within the bone marrow aspirant, suggesting a role of this organ as a reservoir for this parasite stage.
Salazar Álvarez Luis CARLOS, Djane Baia-Da-Silva, Fabio Trindade Maranhão Costa   +2 more
exaly   +3 more sources

Viability and Infectivity of Plasmodium vivax Gametocytes in Short-Term Culture

Frontiers in Cellular and Infection Microbiology, 2021
The control and elimination of malaria caused by Plasmodium vivax both represent a great challenge due to the biological aspects of the species. Gametocytes are the forms responsible for the transmission of the parasite to the vector and the search for ...
Djane Baia-Da-Silva, Wuelton Monteiro, Marcus Vinicius Guimarães Lacerda   +2 more
exaly   +3 more sources

Gene Polymorphisms Among Plasmodium vivax Geographical Isolates and the Potential as New Biomarkers for Gametocyte Detection

Frontiers in Cellular and Infection Microbiology, 2022
The unique biological features of Plasmodium vivax not only make it difficult to control but also to eliminate. For the transmission of the malaria parasite from infected human to the vector, gametocytes play a major role. The transmission potential of a
Anthony Ford, Daniel Kepple, Jonathan Williams, Gabrielle Kolesar, Colby T. Ford, Colby T. Ford, Abnet Abebe, Lemu Golassa, Daniel A. Janies, Delenasaw Yewhalaw, Delenasaw Yewhalaw, Eugenia Lo, Eugenia Lo   +12 more
doaj   +1 more source

The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates

Microbiology Spectrum, 2023
Our overall understanding of the developmental biology of malaria parasites has been greatly enhanced by recent advances in transcriptomic analysis. However, most of these investigations rely on laboratory strains (LS) that were adapted into in vitro ...
Jonas A. Kengne-Ouafo, Saikou Y. Bah, Alison Kemp, Lindsay Stewart, Lucas Amenga-Etego, Kirk W. Deitsch, Julian C. Rayner, Oliver Billker, Fred N. Binka, Colin J. Sutherland, Gordon A. Awandare, Britta C. Urban, Bismarck Dinko   +12 more
doaj   +1 more source

Immunoreactivity of Sera From Low to Moderate Malaria-Endemic Areas Against Plasmodium vivax rPvs48/45 Proteins Produced in Escherichia coli and Chinese Hamster Ovary Systems

Frontiers in Immunology, 2021
P48/45 is a conserved gametocyte antigen involved in Plasmodium parasite fertilization. A recombinant Plasmodium vivax P48/45 (Pvs48/45) protein expressed in Escherichia coli (E.
Myriam Arévalo-Herrera, Myriam Arévalo-Herrera, Kazutoyo Miura, Nora Cespedes, Carlos Echeverry, Eduardo Solano, Angélica Castellanos, Juan Sebastián Ramirez, Adolfo Miranda, Andrey V. Kajava, Carole Long, Giampietro Corradin, Sócrates Herrera, Sócrates Herrera   +13 more
doaj   +1 more source

Assays for quantification of male and female gametocytes in human blood by qRT-PCR in the absence of pure sex-specific gametocyte standards

Malaria Journal, 2020
Background Malaria transmission from humans to Anopheles mosquitoes requires the presence of gametocytes in human peripheral circulation, and the dynamics of transmission are determined largely by the density and sex ratio of the gametocytes.
Claire Y. T. Wang, Emma Ballard, Stacey Llewellyn, Louise Marquart, Teun Bousema, James S. McCarthy, Katharine A. Collins   +6 more
doaj   +1 more source

Revisiting the Effect of Pharmaceuticals on Transmission Stage Formation in the Malaria Parasite Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2022
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites to the sexual differentiation pathway.
Basil T. Thommen, Basil T. Thommen, Armin Passecker, Armin Passecker, Tamara Buser, Tamara Buser, Eva Hitz, Eva Hitz, Till S. Voss, Till S. Voss, Nicolas M. B. Brancucci, Nicolas M. B. Brancucci   +11 more
doaj   +1 more source