Results 1 to 10 of about 13,563 (220)

Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh. [PDF]

, 2004
OBJECTIVE: To assess the efficacy of antimalarial treatment and molecular markers of Plasmodium falciparum resistance in the Chittagong Hill Tracts of Bangladesh. METHODS: A total of 203 patients infected with P.
Anderson, T C, Brockman, A, Chakma, S, Nair, S, Talukder, L, van den Broek, I, van der Wardt, S   +6 more
core   +2 more sources

Clustering Plasmodium falciparum Genes to their Functional Roles Using k-means [PDF]

, 2010
We developed recently a new and novel Metric Matrics k-means (MMk-means) clustering algorithm to cluster genes to their functional roles with a view of obtaining further knowledge on many P. falciparum genes.
Adebiyi, E. F., Doumbia, Seydou, Osamor, V. C.   +2 more
core   +1 more source

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings.

PLoS Pathogens, 2018
Malaria transmission remains high in Sub-Saharan Africa despite large-scale implementation of malaria control interventions. A comprehensive understanding of the transmissibility of infections to mosquitoes may guide the design of more effective ...
André Lin Ouédraogo, Philip A Eckhoff, Adrian J F Luty, Will Roeffen, Robert W Sauerwein, Teun Bousema, Edward A Wenger   +6 more
doaj   +1 more source

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

eLife, 2018
Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema   +20 more
doaj   +1 more source

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data. [PDF]

, 2016
BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors.
WWARN Gametocyte Study Group
core   +1 more source

Dynamics of P. Falciparum Gametocytemia in Symptomatic Patients in an Area of Intense Perennial Transmission in Tanzania. [PDF]

We investigated the dynamics of Plasmodium falciparum gametocytemia in symptomatic patients attending a local dispensary in the Kilombero district, Tanzania.
Akim, N I, Drakeley, C, Kingo, T, Sauerwein, R W, Senkoro, K, Simon, B   +5 more
core  

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Gametocyte clearance in children, from western Kenya, with uncomplicated Plasmodium falciparum malaria after artemether–lumefantrine or dihydroartemisinin–piperaquine treatment

Malaria Journal, 2019
Background The efficacy and safety of artemether–lumefantrine (AL) and dihydroartemisinin–piperaquine (DP) against asexual parasites population has been documented.
Protus Omondi, Marion Burugu, Damaris Matoke-Muhia, Edwin Too, Eva A. Nambati, William Chege, Kelvin B. Musyoka, Kelvin Thiongo, Maureen Otinga, Francis Muregi, Francis Kimani   +10 more
doaj   +1 more source

Age-structured gametocyte allocation links immunity to epidemiology in malaria parasites

Malaria Journal, 2007
Background Despite a long history of attempts to model malaria epidemiology, the over-riding conclusion is that a detailed understanding of host-parasite interactions leading to immunity is required.
Boudin Christian, Bonnet Sarah, Paul Richard E, Tchuinkam Timoleon, Robert Vincent   +4 more
doaj   +1 more source

Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine

Malaria Journal, 2008
Background Amodiaquine is frequently used as a partner drug in combination therapy or in some setting as monotherapy, but little is known about its effects on gametocyte production and sex ratio and its potential influence on transmission in Africa.
Gbotosho Grace O, Balogun Sulayman T, Sowunmi Akintunde, Happi Christian T   +3 more
doaj   +1 more source