Results 11 to 20 of about 9,642 (218)

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs [PDF]

Malaria Journal, 2010
Background There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation ...
Sawa Patrick, Omar Sabah, Griffin Jamie T, Shekalaghe Seif, Okell Lucy, Bousema Teun, Sutherland Colin, Sauerwein Robert, Ghani Azra C, Drakeley Chris   +9 more
doaj   +3 more sources

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea. [PDF]

PLoS ONE, 2015
A better understanding of human-to-mosquito transmission is crucial to control malaria. In order to assess factors associated with gametocyte carriage, 2083 samples were collected in a cross-sectional survey in Papua New Guinea.
Cristian Koepfli, Leanne J Robinson, Patricia Rarau, Mary Salib, Naomi Sambale, Rahel Wampfler, Inoni Betuela, Wang Nuitragool, Alyssa E Barry, Peter Siba, Ingrid Felger, Ivo Mueller   +11 more
doaj   +3 more sources

Strategies for Detection of Plasmodium species Gametocytes [PDF]

PLoS ONE, 2013
Carriage and density of gametocytes, the transmission stages of malaria parasites, are determined for predicting the infectiousness of humans to mosquitoes. This measure is used for evaluating interventions that aim at reducing malaria transmission.
Wampfler, R, Mwingira, F, Javati, S, Robinson, L, Betuela, I, Siba, P, Beck, H-P, Mueller, I, Felger, I   +8 more
openaire   +8 more sources

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data. [PDF]

, 2016
BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors.
Genton, Blaise
core   +8 more sources

The Coming-Out of Malaria Gametocytes [PDF]

Journal of Biomedicine and Biotechnology, 2010
The tropical disease malaria, which results in more than one million deaths annually, is caused by protozoan parasites of the genusPlasmodiumand transmitted by blood-feeding Anopheline mosquitoes. Parasite transition from the human host to the mosquito vector is mediated by gametocytes, sexual stages that are formed in human erythrocytes, which ...
Kuehn, Andrea, Pradel, Gabriele
openaire   +3 more sources

The activity of methylene blue against asexual and sexual stages of Plasmodium vivax

Frontiers in Cellular and Infection Microbiology, 2023
Methylene blue (MB) is an alternative for combating drug-resistant malaria parasites. Its transmission-blocking potential has been demonstrated in vivo in murine models, in vitro, and in clinical trials.
Camila Fabbri, Camila Fabbri, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Glenda Quaresma Ramos, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Djane Clarys Baia-da-Silva, Alexandre Oliveira Trindade, Luis Carlos Salazar-Alvarez, Juliana Costa Ferreira Neves, Juliana Costa Ferreira Neves, Ivanildes dos Santos Bastos, Ivanildes dos Santos Bastos, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Marcus Vinicius Guimarães Lacerda, Wuelton Marcelo Monteiro, Wuelton Marcelo Monteiro, Fabio Trindade Maranhão Costa, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes, Stefanie Costa Pinto Lopes   +27 more
doaj   +1 more source

Plasmodium vivax gametocytes and transmission

Parasitology International, 2022
Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs.
Sirasate, Bantuchai, Hisham, Imad, Wang, Nguitragool   +2 more
openaire   +2 more sources

School-based screening and treatment may reduce P. falciparum transmission

Scientific Reports, 2021
In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact screening-and-treatment of asymptomatic Malawian schoolchildren (n = 364 in the rainy season and 341 in the ...
Lauren M. Cohee, Clarissa Valim, Jenna E. Coalson, Andrew Nyambalo, Moses Chilombe, Andrew Ngwira, Andy Bauleni, Karl B. Seydel, Mark L. Wilson, Terrie E. Taylor, Don P. Mathanga, Miriam K. Laufer   +11 more
doaj   +1 more source

Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. [PDF]

, 2009
BACKGROUND: Man to mosquito transmission of malaria depends on the presence of the sexual stage parasites, gametocytes, that often circulate at low densities. Gametocyte densities below the microscopical threshold of detection may be sufficient to infect
Bousema, Teun, Jan Peter Verhave, Ouedraogo, A.L., Nébié, Issa, Sauerwein Robert, Vlas, S.J. (Sake) de, Nebie, I, Nadine Cuzin-Ouattara, Ouédraogo André Lin, Luty, Adrian JF, de Vlas Sake J., Ilboudo-Sanogo, E., Verhave Jan Peter, Luty, AJF, Nébié Issa, Verhave, Jan Peter, Verhave, J.P. (Jan Peter), Bousema, T., Petra Schneider, Cuzin-Ouattara, N. (Nadine), Ilboudo-Sanogo Edith, Roeffen, W, Cuzin-Ouattara, N., de Vlas, Sake J., Sauerwein, R, Schneider, P., Roeffen, W.F.G., Bousema Teun, Schneider, Pauline, Cuzin-Ouattara, N, Roeffen, Will, André Lin Ouédraogo, Sauerwein, Robert, Adrian J F Luty, Cuzin-Ouattara Nadine, Ouedraogo, AL, Sake J de Vlas, Bousema, T. (Teun), Luty, A.J.F., Sauerwein, R.W., Schneider, Petra, Roeffen, W. (Will), Schneider, P. (Petra), Ilboudo-Sanogo, E, Ouédraogo, André Lin, Cuzin-Ouattara, Nadine, Teun Bousema, Edith Ilboudo-Sanogo, Verhave, JP, Schneider Petra, de Vlas, Sake J, Issa Nébié, Robert Sauerwein, Roeffen Will, Ilboudo-Sanogo, Edith, de Vlas, Sake, Ouédraogo, A.L. (André Lin), Nebie, I., Luty, A.J.F. (Adrian), Bousema, T, Luty Adrian J. F., Verhave, J.P., Nábí, I. (Issa), Luty, Adrian J. F., Vlas, S.J. de, Will Roeffen, Ilboudo-Sanogo, E. (Edith), Sauerwein, R.W. (Robert)   +67 more
core   +4 more sources

Risk factors for Plasmodium falciparum gametocyte positivity in a longitudinal cohort. [PDF]

PLoS ONE, 2015
Malaria transmission intensity is highly heterogeneous even at a very small scale. Implementing targeted intervention in malaria transmission hotspots offers the potential to reduce the burden of disease both locally and in adjacent areas.
Laura Grange, Cheikh Loucoubar, Olivier Telle, Adama Tall, Joseph Faye, Cheikh Sokhna, Jean-François Trape, Anavaj Sakuntabhai, Jean-François Bureau, Richard Paul   +9 more
doaj   +1 more source