Results 11 to 20 of about 13,563 (220)

Antibody Responses to Crude Gametocyte Extract Predict Plasmodium falciparum Gametocyte Carriage in Kenya [PDF]

Frontiers in Immunology, 2021
BackgroundMalaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key to malaria elimination and/or ...
Brian R. Omondi, Brian R. Omondi, Michelle K. Muthui, William I. Muasya, Benedict Orindi, Ramadhan S. Mwakubambanya, Teun Bousema, Chris Drakeley, Kevin Marsh, Kevin Marsh, Philip Bejon, Philip Bejon, Melissa C. Kapulu, Melissa C. Kapulu   +13 more
doaj   +6 more sources

GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum [PDF]

Nature Communications
Transmission of the malaria parasite Plasmodium falciparum requires the formation of specialised sexual cells called gametocytes. A hallmark of P. falciparum gametocyte development is its long duration, during which the parasite undergoes dramatic ...
Danushka S. Marapana, Sash Lopaticki, Balu Balan, Kitsanapong Reaksudsan, Simon A. Cobbold, Niall D. Geoghegan, Sachin Khurana, Stephen W. Scally, Peter Hickey, Niva Jayakrishnan, Vineet Vaibhav, Sukhdeep Spall, Jumana M. Yousef, Laura F. Dagley, Christopher D. Goodman, Anton Cozijnsen, Geoffrey I. McFadden, Kelly L. Rogers, Aaron Jex, David Komander, James S. McCarthy, Christopher J. Tonkin, Matthew W. A. Dixon, Alan F. Cowman   +23 more
doaj   +2 more sources

HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya

Frontiers in Cellular and Infection Microbiology, 2021
As morbidity and mortality due to malaria continue to decline, the identification of individuals with a high likelihood of transmitting malaria is needed to further reduce the prevalence of malaria.
Shirley Luckhart
exaly   +3 more sources

Risk factor for gametocyte carriage and gametocytemia in Plasmodium vivax and Plasmodium falciparum [PDF]

Infectious Diseases of Poverty
Background Understanding Plasmodium sexual differentiation is crucial for blocking transmission. This study identified risk factors for gametocyte carriage and gametocytemia in P. vivax and P.
Minxi Li, Yang Bian, Shishao Ruan, Zifang Wu, Di Zhang, Tongyu Ma, Yaming Wu, Xiao Liu, Duo Wang, Jia Lin, Danni Pan, Wenyan Cui, Lin Wang, Haichao Wei, Xuexing Zhang, Qinghui Wang, Weilin Zeng, Zhaoqing Yang, Yaming Cao, Liwang Cui, Daniel M. Parker, Yan Zhao   +21 more
doaj   +2 more sources

Asymptomatic school-age children carry the majority of transmissible Plasmodium falciparum infections [PDF]

Communications Medicine
Background Persistent human-to-mosquito parasite transmission hinders malaria control in high burden settings. Understanding the human transmission reservoir can support the design of targeted interventions to reduce transmission.
Andrea G. Buchwald, Jimmy Vareta, Otutochukwu Nwagbata, Robert S. McCann, Alick Sixpence, Alfred Matengeni, Moses Kamzati, Charles Mangani, Karl B. Seydel, Mark L. Wilson, Terrie E. Taylor, Don P. Mathanga, Clarissa Valim, Miriam K. Laufer, Lauren M. Cohee   +14 more
doaj   +2 more sources

Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea. [PDF]

PLoS ONE, 2015
A better understanding of human-to-mosquito transmission is crucial to control malaria. In order to assess factors associated with gametocyte carriage, 2083 samples were collected in a cross-sectional survey in Papua New Guinea.
Cristian Koepfli, Leanne J Robinson, Patricia Rarau, Mary Salib, Naomi Sambale, Rahel Wampfler, Inoni Betuela, Wang Nuitragool, Alyssa E Barry, Peter Siba, Ingrid Felger, Ivo Mueller   +11 more
doaj   +8 more sources

Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes. [PDF]

PLoS Pathogens
Reducing malaria transmission has been a major pillar of control programmes and is considered crucial for achieving malaria elimination. Gametocytes, the transmissible forms of the P.
Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E Otoboh, Jahiro Gomez, Lorena Coronado, Karl B Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti   +13 more
doaj   +2 more sources

Prevalence of asymptomatic P. falciparum gametocyte carriage among school children in Mbita, Western Kenya and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research, 2021
Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria.
Abdoulie O. Touray, Victor A. Mobegi, Fred Wamunyokoli, Hellen Butungi, Jeremy K. Herren   +4 more
doaj   +1 more source

Plasmodium falciparum gametocyte carriage in symptomatic patients shows significant association with genetically diverse infections, anaemia, and asexual stage density

Malaria Journal, 2021
Background Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants.
Paul Sondo, Biebo Bihoun, Marc Christian Tahita, Karim Derra, Toussaint Rouamba, Seydou Nakanabo Diallo, Adama Kazienga, Hamidou Ilboudo, Innocent Valea, Zekiba Tarnagda, Hermann Sorgho, Thierry Lefèvre, Halidou Tinto   +12 more
doaj   +1 more source

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Frontiers in Immunology, 2022
Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes.
Roos M. de Jong, Manon Alkema, Tate Oulton, Elin Dumont, Karina Teelen, Rie Nakajima, Rafael Ramiro de Assis, Kathleen W. Dantzler Press, Priscilla Ngotho, Kevin K.A. Tetteh, Phil Felgner, Matthias Marti, Katharine A. Collins, Chris Drakeley, Teun Bousema, Teun Bousema, Will J.R. Stone   +16 more
doaj   +1 more source