Results 11 to 20 of about 18,519 (218)

Antibody Responses to Crude Gametocyte Extract Predict Plasmodium falciparum Gametocyte Carriage in Kenya [PDF]

Frontiers in Immunology, 2021
BackgroundMalaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key to malaria elimination and/or eradication. However, factors that are associated with gametocyte carriage have not been fully explored.
Brian R. Omondi, Brian R. Omondi, Michelle K. Muthui, William I. Muasya, Benedict Orindi, Ramadhan S. Mwakubambanya, Teun Bousema, Chris Drakeley, Kevin Marsh, Kevin Marsh, Philip Bejon, Philip Bejon, Melissa C. Kapulu, Melissa C. Kapulu   +13 more
openaire   +6 more sources

PfAP2-G2 Is Associated to Production and Maturation of Gametocytes in Plasmodium falciparum via Regulating the Expression of PfMDV-1

Frontiers in Microbiology, 2021
Gametocyte is the sole form of the Plasmodium falciparum which is transmissible to the mosquito vector. Here, we report that an Apicomplexan Apetala2 (ApiAP2) family transcription factor, PfAP2-G2 (Pf3D7_1408200), plays a role in the development of ...
Yaozheng Xu, Dan Qiao, Yuhao Wen, Yifei Bi, Yuxi Chen, Zhenghui Huang, Liwang Cui, Jian Guo, Yaming Cao   +8 more
doaj   +1 more source

Immunoreactivity of Sera From Low to Moderate Malaria-Endemic Areas Against Plasmodium vivax rPvs48/45 Proteins Produced in Escherichia coli and Chinese Hamster Ovary Systems

Frontiers in Immunology, 2021
P48/45 is a conserved gametocyte antigen involved in Plasmodium parasite fertilization. A recombinant Plasmodium vivax P48/45 (Pvs48/45) protein expressed in Escherichia coli (E.
Myriam Arévalo-Herrera, Myriam Arévalo-Herrera, Kazutoyo Miura, Nora Cespedes, Carlos Echeverry, Eduardo Solano, Angélica Castellanos, Juan Sebastián Ramirez, Adolfo Miranda, Andrey V. Kajava, Carole Long, Giampietro Corradin, Sócrates Herrera, Sócrates Herrera   +13 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission-blocking target. [PDF]

FEBS Lett
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Huppertz F, Caturelli MS, Lehmann LS, Kurth F, Maier AG, Matuschewski K.   +5 more
europepmc   +2 more sources

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +21 more sources

Phagocytosis and activation of bone marrow‐derived macrophages by Plasmodium falciparum gametocytes

Malaria Journal, 2021
Background The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation of its severity.
Yolanda Corbett, Silvia Parapini, Federica Perego, Valeria Messina, Serena Delbue, Paola Misiano, Mario Falchi, Francesco Silvestrini, Donatella Taramelli, Nicoletta Basilico, Sarah D’Alessandro   +10 more
doaj   +1 more source

Plasmodium vivax gametocytes and transmission

Parasitology International, 2022
Malaria elimination means cessation of parasite transmission. At present, the declining malaria incidence in many countries has made elimination a feasible goal. Transmission control has thus been placed at the center of the national malaria control programs.
Sirasate, Bantuchai, Hisham, Imad, Wang, Nguitragool   +2 more
openaire   +2 more sources

Assays for quantification of male and female gametocytes in human blood by qRT-PCR in the absence of pure sex-specific gametocyte standards

Malaria Journal, 2020
Background Malaria transmission from humans to Anopheles mosquitoes requires the presence of gametocytes in human peripheral circulation, and the dynamics of transmission are determined largely by the density and sex ratio of the gametocytes.
Claire Y. T. Wang, Emma Ballard, Stacey Llewellyn, Louise Marquart, Teun Bousema, James S. McCarthy, Katharine A. Collins   +6 more
doaj   +1 more source

The Coming-Out of Malaria Gametocytes [PDF]

Journal of Biomedicine and Biotechnology, 2010
The tropical disease malaria, which results in more than one million deaths annually, is caused by protozoan parasites of the genusPlasmodiumand transmitted by blood-feeding Anopheline mosquitoes. Parasite transition from the human host to the mosquito vector is mediated by gametocytes, sexual stages that are formed in human erythrocytes, which ...
Kuehn, Andrea, Pradel, Gabriele
openaire   +3 more sources

Revisiting the Effect of Pharmaceuticals on Transmission Stage Formation in the Malaria Parasite Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2022
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites to the sexual differentiation pathway.
Basil T. Thommen, Basil T. Thommen, Armin Passecker, Armin Passecker, Tamara Buser, Tamara Buser, Eva Hitz, Eva Hitz, Till S. Voss, Till S. Voss, Nicolas M. B. Brancucci, Nicolas M. B. Brancucci   +11 more
doaj   +1 more source