Development of reverse-transcription PCR techniques to analyse the density and sex ratio of gametocytes in genetically diverse Plasmodium chabaudi infections [PDF]
, 2007 We have developed cross-genotype and genotype-specific quantitative reverse-transcription PCR (qRT-PCR) assays to detect and quantify the number of parasites, transmission stages (gametocytes) and male gametocytes in blood stage Plasmodium chabaudi ...
Abdel-Wahab +44 more
core +1 more source
Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]
, 2013 Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth +5 more
core +3 more sources
Immune Responses to the Sexual Stages of Plasmodium falciparum Parasites
Frontiers in Immunology, 2019 Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the
Jonas A. Kengne-Ouafo +5 more
doaj +1 more source
Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). [PDF]
, 2007 Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on ...
Alexander, Neal +10 more
core +2 more sources
Memorias do Instituto Oswaldo Cruz, 2002 The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with ...
Lyda Osorio +2 more
doaj +1 more source
The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]
, 2013 Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M +9 more
core +4 more sources
eLife, 2018 Background: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is ...
Isaie J Reuling +20 more
doaj +1 more source
HIV-1 Impact on Malaria Transmission: A Complex and Relevant Global Health Concern
Frontiers in Cellular and Infection Microbiology, 2021 Malaria/HIV-1 co-infection has become a significant public health problem in the tropics where there is geographical overlap of the two diseases. It is well described that co-infection impacts clinical progression of both diseases; however, less is known
Ashleigh Roberds +3 more
doaj +1 more source
Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.
, 2009 Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew +5 more
core +1 more source
Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]
, 2017 Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani +5 more
core +1 more source