Results 31 to 40 of about 803 (130)

Plasmodium falciparumgametocytes: with a view to a kill [PDF]

Parasitology, 2013
SUMMARYDrugs that kill or inhibit the sexual stages ofPlasmodiumin order to prevent transmission are important components of malaria control programmes. Reducing gametocyte carriage is central to the control ofPlasmodium falciparumtransmission as infection can result in extended periods of gametocytaemia. Unfortunately the number of drugs with activity
Butterworth, Alice S, Skinner-Adams, Tina S, Gardiner, Don L, Trenholme, Katharine R   +3 more
openaire   +5 more sources

Testing possible causes of gametocyte reduction in temporally out-of-synch malaria infections

Malaria Journal, 2020
Background The intraerythrocytic development cycle (IDC) of the rodent malaria Plasmodium chabaudi is coordinated with host circadian rhythms. When this coordination is disrupted, parasites suffer a 50% reduction in both asexual stages and sexual stage ...
Mary L. Westwood, Aidan J. O’Donnell, Petra Schneider, Gregory F. Albery, Kimberley F. Prior, Sarah E. Reece   +5 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2017
Transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by the intraerythrocytic gametocytes, which, once taken up during a blood meal, become activated to initiate sexual reproduction.
Che J. Ngwa, Meike J. Kiesow, Olga Papst, Lindsey M. Orchard, Michael Filarsky, Alina N. Rosinski, Till S. Voss, Manuel Llinás, Manuel Llinás, Gabriele Pradel   +9 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Gametocyte carriage in Plasmodium falciparum-infected travellers [PDF]

Malaria Journal, 2013
Abstract Background Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Roberts, CH, Armstrong, M, Zatyka, E, Boadi, S, Warren, S, Chiodini, PL, Sutherland, CJ, Doherty, T   +7 more
openaire   +5 more sources

Defining the signature of deformable and infectious Plasmodium falciparum gametocytes [version 3; peer review: 3 approved]

Wellcome Open Research
Background One of the major challenges for malaria elimination is combating the highly efficient spread of the disease. Despite progress in understanding the development of malaria transmission stages, there remain many unanswered questions about how ...
Martijn Huijnen, Teun Bousema, Sanna Rijpma, Wouter Graumans, Matthias Marti, Dario Beraldi, Kathryn crouch, Lisette Meerstein-Kessel, Geert-Jan van Gemert, Deepali Ravel, Armin Passecker, Emmanuel Arinaitwe, Sara Lynn Blanken, Priscilla Ngotho, Stoter Rianne, Daniel Neafsey, Till Voss   +16 more
doaj   +1 more source

Unraveling Occurrence Patterns and Diversity of Avian Malaria Parasites in Iberian Obligate and Facultative Scavenger Birds

Integrative Zoology, EarlyView.
Low overall haemosporidian occurrence (3.4%; 13/383). Unexpected high lineage diversity (10 new host–parasite interactions). Novel Leucocytozoon lineage (GYPBAR01) in all European vultures except the griffon vulture. Plasmodium relictum (lineage SGS1) in adult red kites.
Pilar Oliva‐Vidal, Jaime Muriel, Alfonso Marzal, Grethell Mabel López del Aguila, José María Martínez, Antoni Margalida   +5 more
wiley   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source